Spiegel PC - Search Results

1

Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction.

Coyle CW, Knight KA, Brown HC, George SN, Denning G, Branella GM, Childers KC, Spiegel PC, Spencer HT, Doering CB. Coyle CW, et al. Among authors: spiegel pc. J Thromb Haemost. 2024 Mar;22(3):633-644. doi: 10.1016/j.jtha.2023.11.010. Epub 2023 Nov 26. J Thromb Haemost. 2024. PMID: 38016519

2

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.

Smith IW, d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC Jr. Smith IW, et al. Among authors: spiegel pc jr. J Thromb Haemost. 2020 Jan;18(1):57-69. doi: 10.1111/jth.14621. Epub 2019 Sep 8. J Thromb Haemost. 2020. PMID: 31454152 Free PMC article.

3

Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.

Gish JS, Jarvis L, Childers KC, Peters SC, Garrels CS, Smith IW, Spencer HT, Doering CB, Lollar P, Spiegel PC. Gish JS, et al. Among authors: spiegel pc. Blood. 2021 May 27;137(21):2981-2986. doi: 10.1182/blood.2020008940. Blood. 2021. PMID: 33529335 Free PMC article.

4

Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor.

Ronayne EK, Peters SC, Gish JS, Wilson C, Spencer HT, Doering CB, Lollar P, Spiegel PC Jr, Childers KC. Ronayne EK, et al. Among authors: spiegel pc jr. Front Immunol. 2021 Jun 10;12:697602. doi: 10.3389/fimmu.2021.697602. eCollection 2021. Front Immunol. 2021. PMID: 34177966 Free PMC article.

5

SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa.

Childers KC, Peters SC, Lollar P, Spencer HT, Doering CB, Spiegel PC. Childers KC, et al. Among authors: spiegel pc. Blood Adv. 2022 Jun 14;6(11):3240-3254. doi: 10.1182/bloodadvances.2021005874. Blood Adv. 2022. PMID: 35255502 Free PMC article.

6

Structural insights into blood coagulation factor VIII: Procoagulant complexes, membrane binding, and antibody inhibition.

Childers KC, Peters SC, Spiegel PC Jr. Childers KC, et al. Among authors: spiegel pc jr. J Thromb Haemost. 2022 Sep;20(9):1957-1970. doi: 10.1111/jth.15793. Epub 2022 Jul 11. J Thromb Haemost. 2022. PMID: 35722946 Free article. Review.

7

Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.

Peters SC, Childers KC, Mitchell CE, Avery NG, Reese SS Jr, Mitchell C, Wo SW, Swanson CD, Brison CM, Spiegel PC Jr. Peters SC, et al. Among authors: spiegel pc jr. Front Mol Biosci. 2022 Oct 26;9:1040106. doi: 10.3389/fmolb.2022.1040106. eCollection 2022. Front Mol Biosci. 2022. PMID: 36387287 Free PMC article.

8

Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain.

Childers KC, Cowper B, Vaughan JD, McGill JR, Davulcu O, Lollar P, Doering CB, Coxon CH, Spiegel PC Jr. Childers KC, et al. Among authors: spiegel pc jr. J Thromb Haemost. 2024 Sep;22(9):2449-2459. doi: 10.1016/j.jtha.2024.05.024. Epub 2024 Jun 5. J Thromb Haemost. 2024. PMID: 38849084

9

The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

Brison CM, Mullen SM, Wuerth ME, Podolsky K, Cook M, Herman JA, Walter JD, Meeks SL, Spiegel PC. Brison CM, et al. Among authors: spiegel pc. PLoS One. 2015 Mar 16;10(3):e0122447. doi: 10.1371/journal.pone.0122447. eCollection 2015. PLoS One. 2015. PMID: 25775247 Free PMC article.

10

Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies.

Walter JD, Werther RA, Polozova MS, Pohlman J, Healey JF, Meeks SL, Lollar P, Spiegel PC Jr. Walter JD, et al. Among authors: spiegel pc jr. J Biol Chem. 2013 Apr 5;288(14):9905-9914. doi: 10.1074/jbc.M112.424564. Epub 2013 Feb 15. J Biol Chem. 2013. PMID: 23417672 Free PMC article.

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