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149 results

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Page 1
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
Fowler JL, Zheng SL, Nguyen A, Chen A, Xiong X, Chai T, Chen JY, Karigane D, Banuelos AM, Niizuma K, Kayamori K, Nishimura T, Cromer MK, Gonzalez-Perez D, Mason C, Liu DD, Yilmaz L, Miquerol L, Porteus MH, Luca VC, Majeti R, Nakauchi H, Red-Horse K, Weissman IL, Ang LT, Loh KM. Fowler JL, et al. Among authors: porteus mh. Dev Cell. 2024 May 6;59(9):1110-1131.e22. doi: 10.1016/j.devcel.2024.03.003. Epub 2024 Apr 2. Dev Cell. 2024. PMID: 38569552 Free PMC article.
Genetically corrected RAG2-SCID human hematopoietic stem cells restore V(D)J-recombinase and rescue lymphoid deficiency.
Pavel-Dinu M, Gardner CL, Nakauchi Y, Kawai T, Delmonte OM, Palterer B, Bosticardo M, Pala F, Viel S, Malech HL, Ghanim HY, Bode NM, Kurgan GL, Detweiler AM, Vakulskas CA, Neff NF, Sheikali A, Menezes ST, Chrobok J, Hernández González EM, Majeti R, Notarangelo LD, Porteus MH. Pavel-Dinu M, et al. Among authors: porteus mh. Blood Adv. 2024 Apr 9;8(7):1820-1833. doi: 10.1182/bloodadvances.2023011766. Blood Adv. 2024. PMID: 38096800 Free PMC article.
iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer.
Furukawa Y, Ishii M, Ando J, Ikeda K, Igarashi KJ, Kinoshita S, Azusawa Y, Toyota T, Honda T, Nakanishi M, Ohshima K, Masuda A, Yoshida E, Kitade M, Porteus M, Terao Y, Nakauchi H, Ando M. Furukawa Y, et al. Cell Rep Med. 2023 Dec 19;4(12):101327. doi: 10.1016/j.xcrm.2023.101327. Epub 2023 Dec 12. Cell Rep Med. 2023. PMID: 38091985 Free PMC article.
Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells.
Chu SN, Soupene E, Sharma D, Sinha R, McCreary T, Hernandez B, Shen H, Wienert B, Bowman C, Yin H, Lesch BJ, Jia K, Romero KA, Kostamo Z, Zhang Y, Tran T, Cordero M, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Sheehan VA, Porteus MH, Cromer MK. Chu SN, et al. Among authors: porteus mh. Cell Rep. 2025 Jan 3;44(1):115141. doi: 10.1016/j.celrep.2024.115141. Online ahead of print. Cell Rep. 2025. PMID: 39754719 Free article.
TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function.
Dimitri AJ, Baxter AE, Chen GM, Hopkins CR, Rouin GT, Huang H, Kong W, Holliday CH, Wiebking V, Bartoszek R, Drury S, Dalton K, Koucky OM, Chen Z, Giles JR, Dils AT, Jung IY, O'Connor R, Collins S, Everett JK, Amses K, Sherrill-Mix S, Chandra A, Goldman N, Vahedi G, Jadlowsky JK, Young RM, Melenhorst JJ, Maude SL, Levine BL, Frey NV, Berger SL, Grupp SA, Porter DL, Herbst F, Porteus MH, Carty SA, Bushman FD, Weber EW, Wherry EJ, Jordan MS, Fraietta JA. Dimitri AJ, et al. Among authors: porteus mh. Sci Adv. 2024 Nov 15;10(46):eadp9371. doi: 10.1126/sciadv.adp9371. Epub 2024 Nov 13. Sci Adv. 2024. PMID: 39536093 Free PMC article.
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis.
Wang W, Arreola M, Mathews T, DeVilbiss A, Zhao Z, Martin-Sandoval M, Mohammed A, Benegiamo G, Awani A, Goeminne L, Dever D, Nakauchi Y, Porteus MH, Pavel-Dinu M, Al-Herz W, Auwerx J, Morrison SJ, Weinacht KG. Wang W, et al. Among authors: porteus mh. Blood. 2024 Dec 26;144(26):2718-2734. doi: 10.1182/blood.2024024123. Blood. 2024. PMID: 39378586
Cell and gene therapy accessibility.
Rouce RH, Porteus MH. Rouce RH, et al. Among authors: porteus mh. Science. 2024 Aug 2;385(6708):475. doi: 10.1126/science.ads0252. Epub 2024 Aug 1. Science. 2024. PMID: 39088615
149 results