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Page 1
Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates.
Uddin A, Gupta S, Shoaib R, Aneja B, Irfan I, Gupta K, Rawat N, Combrinck J, Kumar B, Aleem M, Hasan P, Joshi MC, Chhonker YS, Zahid M, Hussain A, Pandey K, Alajmi MF, Murry DJ, Egan TJ, Singh S, Abid M. Uddin A, et al. Among authors: combrinck j. Eur J Med Chem. 2024 Jan 15;264:115969. doi: 10.1016/j.ejmech.2023.115969. Epub 2023 Nov 25. Eur J Med Chem. 2024. PMID: 38039787
Fate of haem iron in the malaria parasite Plasmodium falciparum.
Egan TJ, Combrinck JM, Egan J, Hearne GR, Marques HM, Ntenteni S, Sewell BT, Smith PJ, Taylor D, van Schalkwyk DA, Walden JC. Egan TJ, et al. Among authors: combrinck jm. Biochem J. 2002 Jul 15;365(Pt 2):343-7. doi: 10.1042/BJ20020793. Biochem J. 2002. PMID: 12033986 Free PMC article.
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
Gabryszewski SJ, Dhingra SK, Combrinck JM, Lewis IA, Callaghan PS, Hassett MR, Siriwardana A, Henrich PP, Lee AH, Gnädig NF, Musset L, Llinás M, Egan TJ, Roepe PD, Fidock DA. Gabryszewski SJ, et al. Among authors: combrinck jm. PLoS Pathog. 2016 Nov 10;12(11):e1005976. doi: 10.1371/journal.ppat.1005976. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27832198 Free PMC article.
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.
Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE, Alano P, Delves MJ, Lee Sim K, Winzeler EA, Egan TJ, Hoffman SL, Avery VM, Fidock DA. Vanaerschot M, et al. Among authors: combrinck jm. Nat Microbiol. 2017 Oct;2(10):1403-1414. doi: 10.1038/s41564-017-0007-4. Epub 2017 Aug 14. Nat Microbiol. 2017. PMID: 28808258 Free PMC article.
Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites.
L'abbate FP, Müller R, Openshaw R, Combrinck JM, de Villiers KA, Hunter R, Egan TJ. L'abbate FP, et al. Among authors: combrinck jm. Eur J Med Chem. 2018 Nov 5;159:243-254. doi: 10.1016/j.ejmech.2018.09.060. Epub 2018 Sep 28. Eur J Med Chem. 2018. PMID: 30296683 Free PMC article.
26 results