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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Harrison DE, et al. Among authors: sarnoski ea. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2. Geroscience. 2024. PMID: 38041783 Free PMC article.
The Systems Biology of Single-Cell Aging.
Song R, Sarnoski EA, Acar M. Song R, et al. Among authors: sarnoski ea. iScience. 2018 Sep 28;7:154-169. doi: 10.1016/j.isci.2018.08.023. Epub 2018 Sep 3. iScience. 2018. PMID: 30267677 Free PMC article. Review.
Biomarkers to identify and isolate senescent cells.
Matjusaitis M, Chin G, Sarnoski EA, Stolzing A. Matjusaitis M, et al. Among authors: sarnoski ea. Ageing Res Rev. 2016 Aug;29:1-12. doi: 10.1016/j.arr.2016.05.003. Epub 2016 May 20. Ageing Res Rev. 2016. PMID: 27212009 Review.
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Wiley CD, et al. Among authors: sarnoski ea. Cell Metab. 2016 Feb 9;23(2):303-14. doi: 10.1016/j.cmet.2015.11.011. Epub 2015 Dec 10. Cell Metab. 2016. PMID: 26686024 Free PMC article.