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In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin.
Dichamp J, Cellière G, Ghallab A, Hassan R, Boissier N, Hofmann U, Reinders J, Sezgin S, Zühlke S, Hengstler JG, Drasdo D. Dichamp J, et al. Among authors: hofmann u. Front Bioeng Biotechnol. 2023 Feb 2;11:1049564. doi: 10.3389/fbioe.2023.1049564. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 36815881 Free PMC article.
Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.
Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Mattsson J, Marschall HU, Hoehme S, Stirnimann G, Schwab M, Boor P, Amann K, Schmitz J, Bräsen JH, Rahnenführer J, Edlund K, Karpen SJ, Simbrunner B, Reiberger T, Mandorfer M, Trauner M, Dawson PA, Lindström E, Hengstler JG. Ghallab A, et al. Among authors: hofmann u. J Hepatol. 2024 Feb;80(2):268-281. doi: 10.1016/j.jhep.2023.10.035. Epub 2023 Nov 7. J Hepatol. 2024. PMID: 37939855 Free PMC article.
Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice.
Fendt R, Ghallab A, Myllys M, Hofmann U, Hassan R, Hobloss Z, González D, Brackhagen L, Marchan R, Edlund K, Seddek AL, Abdelmageed N, Blank LM, Schlender JF, Holland CH, Hengstler JG, Kuepfer L. Fendt R, et al. Among authors: hofmann u. Front Pharmacol. 2023 Nov 20;14:1279357. doi: 10.3389/fphar.2023.1279357. eCollection 2023. Front Pharmacol. 2023. PMID: 38053838 Free PMC article.
Biomarkers for hypertrophic chondrocyte differentiation are associated with spatial cellular organisation and suggest endochondral ossification-like processes in osteoarthritic cartilage: An exploratory study.
Wolfgart JM, Grötzner LC, Hemayatkar-Fink S, Schwitalle M, Bonnaire FC, Feierabend M, Danalache M, Hofmann UK. Wolfgart JM, et al. Among authors: hofmann uk. J Orthop Translat. 2024 Sep 13;48:232-243. doi: 10.1016/j.jot.2024.08.006. eCollection 2024 Sep. J Orthop Translat. 2024. PMID: 39314759 Free PMC article.
526 results