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Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses.
Yang S, Sheffer M, Kaplan IE, Wang Z, Tarannum M, Dinh K, Abdulhamid Y, Bobilev E, Shapiro R, Porter R, Soiffer R, Ritz J, Koreth J, Wei Y, Chen P, Zhang K, Márquez-Pellegrin V, Bonanno S, Joshi N, Guan M, Yang M, Li D, Bellini C, Liu F, Chen J, Wu CJ, Barbie D, Li J, Romee R. Yang S, et al. Among authors: kaplan ie. Nat Biotechnol. 2024 Oct 4. doi: 10.1038/s41587-024-02418-6. Online ahead of print. Nat Biotechnol. 2024. PMID: 39367093
CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer.
Tarannum M, Dinh K, Vergara J, Birch G, Abdulhamid YZ, Kaplan IE, Ay O, Maia A, Beaver O, Sheffer M, Shapiro R, Ali AK, Dong H, Ham JD, Bobilev E, James S, Cameron AB, Nguyen QD, Ganapathy S, Chayawatto C, Koreth J, Paweletz CP, Gokhale PC, Barbie DA, Matulonis UA, Soiffer RJ, Ritz J, Porter RL, Chen J, Romee R. Tarannum M, et al. Among authors: kaplan ie. Sci Adv. 2024 Jul 12;10(28):eadn0881. doi: 10.1126/sciadv.adn0881. Epub 2024 Jul 12. Sci Adv. 2024. PMID: 38996027 Free PMC article.
Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy.
Yang S, Sheffer M, Kaplan IE, Wang Z, Tarannum M, Dinh K, Abdulhamid Y, Shapiro R, Porter R, Soiffer R, Ritz J, Koreth J, Wei Y, Chen P, Zhang K, Márquez-Pellegrin V, Bonanno S, Joshi N, Guan M, Yang M, Li D, Bellini C, Chen J, Wu CJ, Barbie D, Li J, Romee R. Yang S, et al. Among authors: kaplan ie. Res Sq [Preprint]. 2024 Mar 22:rs.3.rs-4031911. doi: 10.21203/rs.3.rs-4031911/v1. Res Sq. 2024. Update in: Nat Biotechnol. 2024 Oct 4. doi: 10.1038/s41587-024-02418-6 PMID: 38562821 Free PMC article. Updated. Preprint.
CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns.
Stergas HR, Dillon-Martin M, Dumas CM, Hansen NA, Carasi-Schwartz FJ, D'Amico AR, Finnegan KM, Juch U, Kane KR, Kaplan IE, Masengarb ML, Melero ME, Meyer LE, Sacher CR, Scriven EA, Ebert AM, Ballif BA. Stergas HR, et al. Among authors: kaplan ie. FEBS Lett. 2024 Feb;598(3):302-320. doi: 10.1002/1873-3468.14781. Epub 2023 Dec 14. FEBS Lett. 2024. PMID: 38058169