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Nedd4 controls animal growth by regulating IGF-1 signaling.
Cao XR, Lill NL, Boase N, Shi PP, Croucher DR, Shan H, Qu J, Sweezer EM, Place T, Kirby PA, Daly RJ, Kumar S, Yang B. Cao XR, et al. Among authors: sweezer em. Sci Signal. 2008 Sep 23;1(38):ra5. doi: 10.1126/scisignal.1160940. Sci Signal. 2008. PMID: 18812566 Free PMC article.
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.
Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B. Shi PP, et al. Among authors: sweezer em. Am J Physiol Renal Physiol. 2008 Aug;295(2):F462-70. doi: 10.1152/ajprenal.90300.2008. Epub 2008 Jun 4. Am J Physiol Renal Physiol. 2008. PMID: 18524855 Free PMC article.