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Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
Francotte P, Bay Y, Goffin E, Colson T, Lesenfants C, Dorosz J, Laulumaa S, Fraikin P, de Tullio P, Beaufour C, Botez I, Pickering DS, Frydenvang K, Danober L, Kristensen AS, Kastrup JS, Pirotte B. Francotte P, et al. Among authors: goffin e. Eur J Med Chem. 2024 Jan 15;264:116036. doi: 10.1016/j.ejmech.2023.116036. Epub 2023 Dec 9. Eur J Med Chem. 2024. PMID: 38101041 Free article.
New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring.
Goffin E, Fraikin P, Abboud D, de Tullio P, Beaufour C, Botez I, Hanson J, Danober L, Francotte P, Pirotte B. Goffin E, et al. Eur J Med Chem. 2023 Mar 15;250:115221. doi: 10.1016/j.ejmech.2023.115221. Epub 2023 Feb 24. Eur J Med Chem. 2023. PMID: 36863228
Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice.
Oury C, Meyers S, Jacques N, Leeten K, Jiang Z, Musumeci L, Lox M, Debuisson M, Goffin E, Pirotte B, Delvenne P, Nchimi A, Hubert C, Heptia M, Hubert P, Kuijpers MJE, Vanassche T, Martinod K, Verhamme P, Lancellotti P. Oury C, et al. Among authors: goffin e. JACC Basic Transl Sci. 2023 May 24;8(11):1439-1453. doi: 10.1016/j.jacbts.2023.02.003. eCollection 2023 Nov. JACC Basic Transl Sci. 2023. PMID: 38093743 Free PMC article.
Ticagrelor alters the membrane of Staphylococcus aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance.
Leeten K, Jacques N, Esquembre LA, Schneider DC, Straetener J, Henriksen C, Musumeci L, Putters F, Melo S, Sánchez-López E, Giera M, Penoy N, Piel G, Verlaine O, Amoroso A, Joris B, Slavetinsky CJ, Goffin E, Pirotte B, Frees D, Brötz-Oesterhelt H, Lancellotti P, Oury C. Leeten K, et al. Among authors: goffin e. mBio. 2024 Oct 16;15(10):e0132224. doi: 10.1128/mbio.01322-24. Epub 2024 Sep 23. mBio. 2024. PMID: 39311589 Free PMC article.
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma.
El-Hachem N, Leclercq M, Susaeta Ruiz M, Vanleyssem R, Shostak K, Körner PR, Capron C, Martin-Morales L, Roncarati P, Lavergne A, Blomme A, Turchetto S, Goffin E, Thandapani P, Tarassov I, Nguyen L, Pirotte B, Chariot A, Marine JC, Herfs M, Rapino F, Agami R, Close P. El-Hachem N, et al. Among authors: goffin e. Nat Cell Biol. 2024 Jul;26(7):1154-1164. doi: 10.1038/s41556-024-01439-2. Epub 2024 Jun 7. Nat Cell Biol. 2024. PMID: 38849541 Free PMC article.
Basiliximab vs. No Induction Therapy in Kidney Transplant Recipients with a Low Immunological Risk Profile Receiving Tacrolimus/Mycophenolate/Steroids Maintenance Immunosuppression.
Lacave F, de Terwangne C, Darius T, Buemi A, Mourad M, France Y, Cardoso Coelho J, Fernandes G, Goffin E, Devresse A, Kanaan N. Lacave F, et al. Among authors: goffin e. J Clin Med. 2024 Oct 16;13(20):6151. doi: 10.3390/jcm13206151. J Clin Med. 2024. PMID: 39458101 Free PMC article.
299 results