Smith DM - Search Results

1

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors.

Heitmann T, Liao G, de León P, Ernst G, Buchler I, Wei H, Shlevkov E, Brown D, Fitzek M, Collier M, Smith DM, Barrow JC. Heitmann T, et al. Among authors: smith dm. ACS Med Chem Lett. 2023 Nov 28;14(12):1760-1766. doi: 10.1021/acsmedchemlett.3c00409. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116421 Free PMC article.

2

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition.

Brito H, Marques V, Afonso MB, Brown DG, Börjesson U, Selmi N, Smith DM, Roberts IO, Fitzek M, Aniceto N, Guedes RC, Moreira R, Rodrigues CMP. Brito H, et al. Among authors: smith dm. Cell Death Discov. 2020 Feb 11;6:6. doi: 10.1038/s41420-020-0240-0. eCollection 2020. Cell Death Discov. 2020. PMID: 32123582 Free PMC article.

3

A small molecule inhibitor of HER3: a proof-of-concept study.

Colomba A, Fitzek M, George R, Weitsman G, Roberts S, Zanetti-Domingues L, Hirsch M, Rolfe DJ, Mehmood S, Madin A, Claus J, Kjaer S, Snijders AP, Ng T, Martin-Fernandez M, Smith DM, Parker PJ. Colomba A, et al. Among authors: smith dm. Biochem J. 2020 Sep 18;477(17):3329-3347. doi: 10.1042/BCJ20200496. Biochem J. 2020. PMID: 32815546 Free PMC article.

4

Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation.

Parafati M, Bae SH, Kirby RJ, Fitzek M, Iyer P, Engkvist O, Smith DM, Malany S. Parafati M, et al. Among authors: smith dm. Int J Mol Sci. 2020 Dec 15;21(24):9557. doi: 10.3390/ijms21249557. Int J Mol Sci. 2020. PMID: 33334026 Free PMC article.

5

Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus.

Miah M, Davis AM, Hannoun C, Said JS, Fitzek M, Preston M, Smith D, Uwamariya C, Kärmander A, Lundbäck T, Bergström T, Trybala E. Miah M, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106423. doi: 10.1128/aac.01064-23. Epub 2024 Feb 13. Antimicrob Agents Chemother. 2024. PMID: 38349161 Free PMC article.

6

High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS.

Ismail M, Davies G, Sproat G, Monteverde T, Tart J, Acebrón-García-de-Eulate M, Gohlke A, Hancock D, Adhikari S, Stefanovic-Barrett S, Smith DM, Flemington V, Gleave-Hanford ES, Holdgate GA, Kettle JG, Downward J. Ismail M, et al. Among authors: smith dm. SLAS Discov. 2024 Dec;29(8):100197. doi: 10.1016/j.slasd.2024.100197. Epub 2024 Nov 28. SLAS Discov. 2024. PMID: 39613028 Free article.

7

A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets.

Mullooly N, Smith DM, Gianni D. Mullooly N, et al. Among authors: smith dm. SLAS Discov. 2023 Mar;28(2):3-12. doi: 10.1016/j.slasd.2023.01.002. Epub 2023 Jan 13. SLAS Discov. 2023. PMID: 36646173 Free article.

8

AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes.

Bustraan S, Bennett J, Whilding C, Pennycook BR, Smith D, Barr AR, Read J, Carling D, Pollard A. Bustraan S, et al. Biochem J. 2024 Mar 6;481(5):345-362. doi: 10.1042/BCJ20240003. Biochem J. 2024. PMID: 38314646 Free PMC article.

9

Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants.

Ford BE, Chachra SS, Alshawi A, Oakley F, Fairclough RJ, Smith DM, Tiniakos D, Agius L. Ford BE, et al. Among authors: smith dm. Biochem Pharmacol. 2024 Nov;229:116499. doi: 10.1016/j.bcp.2024.116499. Epub 2024 Aug 20. Biochem Pharmacol. 2024. PMID: 39173844 Free article.

10

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.

Ford BE, Chachra SS, Rodgers K, Moonira T, Al-Oanzi ZH, Anstee QM, Reeves HL, Schattenberg JM, Fairclough RJ, Smith DM, Tiniakos D, Agius L. Ford BE, et al. Among authors: smith dm. Mol Metab. 2023 Jun;72:101722. doi: 10.1016/j.molmet.2023.101722. Epub 2023 Apr 7. Mol Metab. 2023. PMID: 37031802 Free PMC article.

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