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Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.
Bahnassawy L, Nicolaisen N, Untucht C, Mielich-Süss B, Reinhardt L, Ried JS, Morawe MP, Geist D, Finck A, Käfer E, Korffmann J, Townsend M, Ravikumar B, Lakics V, Cik M, Reinhardt P. Bahnassawy L, et al. SLAS Discov. 2024 Mar;29(2):100137. doi: 10.1016/j.slasd.2023.12.009. Epub 2023 Dec 19. SLAS Discov. 2024. PMID: 38128829 Free article.
Functional characterization of a single nucleotide polymorphism associated with Alzheimer's disease in a hiPSC-based neuron model.
Stolzenburg LR, Esmaeeli S, Kulkarni AS, Murphy E, Kwon T, Preiss C, Bahnassawy L, Stender JD, Manos JD, Reinhardt P, Rahimov F, Waring JF, Ramathal CY. Stolzenburg LR, et al. Among authors: bahnassawy l. PLoS One. 2023 Sep 26;18(9):e0291029. doi: 10.1371/journal.pone.0291029. eCollection 2023. PLoS One. 2023. PMID: 37751459 Free PMC article.
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.
Schmid B, Holst B, Clausen C, Bahnassawy L, Reinhardt P, Bakker MHM, Díaz-Guerra E, Vicario C, Martino-Adami PV, Thoenes M, Ramirez A, Fliessbach K, Grezella C, Brüstle O, Peitz M, Ebneth A, Cabrera-Socorro A. Schmid B, et al. Among authors: bahnassawy l. Stem Cell Res. 2021 Apr;52:102180. doi: 10.1016/j.scr.2021.102180. Epub 2021 Feb 2. Stem Cell Res. 2021. PMID: 33556820 Free article.
Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.
Petros AM, Korepanova A, Jakob CG, Qiu W, Panchal SC, Wang J, Dietrich JD, Brewer JT, Pohlki F, Kling A, Wilcox K, Lakics V, Bahnassawy L, Reinhardt P, Partha SK, Bodelle PM, Lake M, Charych EI, Stoll VS, Sun C, Mohler EG. Petros AM, et al. Among authors: bahnassawy l. J Med Chem. 2019 Apr 25;62(8):4120-4130. doi: 10.1021/acs.jmedchem.9b00178. Epub 2019 Apr 12. J Med Chem. 2019. PMID: 30933499
13 results