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Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris JC, Don AS, Garfield A, Zarini S, Zemski Berry KA, Ryan AP, Bergman BC, Brozinick JT, James DE, Burchfield JG. Diaz-Vegas A, et al. Among authors: cooke kc. Elife. 2023 Dec 27;12:RP87340. doi: 10.7554/eLife.87340. Elife. 2023. PMID: 38149844 Free PMC article.
Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1).
Duan X, Krycer JR, Cooke KC, Yang G, James DE, Fazakerley DJ. Duan X, et al. Among authors: cooke kc. Biochemistry. 2018 Jul 3;57(26):3606-3615. doi: 10.1021/acs.biochem.8b00361. Epub 2018 Jun 7. Biochemistry. 2018. PMID: 29787242
RagC phosphorylation autoregulates mTOR complex 1.
Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE. Yang G, et al. Among authors: cooke kc. EMBO J. 2019 Feb 1;38(3):e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14. EMBO J. 2019. PMID: 30552228 Free PMC article.
ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation.
Stöckli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, Kebede MA, Humphrey SJ, James DE. Stöckli J, et al. Among authors: cooke kc. Mol Metab. 2019 Jul;25:83-94. doi: 10.1016/j.molmet.2019.05.002. Epub 2019 May 6. Mol Metab. 2019. PMID: 31105056 Free PMC article.
Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.
Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE. Nelson ME, et al. Among authors: cooke kc. EMBO J. 2019 Dec 16;38(24):e102578. doi: 10.15252/embj.2019102578. Epub 2019 Aug 5. EMBO J. 2019. PMID: 31381180 Free PMC article.
Lactate production is a prioritized feature of adipocyte metabolism.
Krycer JR, Quek LE, Francis D, Fazakerley DJ, Elkington SD, Diaz-Vegas A, Cooke KC, Weiss FC, Duan X, Kurdyukov S, Zhou PX, Tambar UK, Hirayama A, Ikeda S, Kamei Y, Soga T, Cooney GJ, James DE. Krycer JR, et al. Among authors: cooke kc. J Biol Chem. 2020 Jan 3;295(1):83-98. doi: 10.1074/jbc.RA119.011178. Epub 2019 Nov 5. J Biol Chem. 2020. PMID: 31690627 Free PMC article.
Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes.
Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: cooke kc. J Biol Chem. 2020 Jan 3;295(1):99-110. doi: 10.1074/jbc.RA119.011695. Epub 2019 Nov 19. J Biol Chem. 2020. PMID: 31744882 Free PMC article.
Insulin signaling requires glucose to promote lipid anabolism in adipocytes.
Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, Nelson ME, Diaz-Vegas A, Humphrey SJ, Scalzo R, Hirayama A, Ikeda S, Shoji F, Suzuki K, Huynh K, Giles C, Varney B, Nagarajan SR, Hoy AJ, Soga T, Meikle PJ, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: cooke kc. J Biol Chem. 2020 Sep 18;295(38):13250-13266. doi: 10.1074/jbc.RA120.014907. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723868 Free PMC article.
28 results