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Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy.
Ndembe G, Intini I, Moro M, Grasselli C, Panfili A, Panini N, Bleve A, Occhipinti M, Borzi C, Garassino MC, Marabese M, Canesi S, Scanziani E, Sozzi G, Broggini M, Ganzinelli M. Ndembe G, et al. Among authors: broggini m. J Exp Clin Cancer Res. 2024 Jan 2;43(1):6. doi: 10.1186/s13046-023-02933-5. J Exp Clin Cancer Res. 2024. PMID: 38163906 Free PMC article.
Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC.
Moro M, Caiola E, Ganzinelli M, Zulato E, Rulli E, Marabese M, Centonze G, Busico A, Pastorino U, de Braud FG, Vernieri C, Simbolo M, Bria E, Scarpa A, Indraccolo S, Broggini M, Sozzi G, Garassino MC. Moro M, et al. Among authors: broggini m. J Thorac Oncol. 2018 Nov;13(11):1692-1704. doi: 10.1016/j.jtho.2018.07.102. Epub 2018 Aug 24. J Thorac Oncol. 2018. PMID: 30149143 Free article.
Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach.
Caiola E, Falcetta F, Giordano S, Marabese M, Garassino MC, Broggini M, Pastorelli R, Brunelli L. Caiola E, et al. Among authors: broggini m. J Exp Clin Cancer Res. 2018 Dec 4;37(1):302. doi: 10.1186/s13046-018-0954-5. J Exp Clin Cancer Res. 2018. PMID: 30514331 Free PMC article.
Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial.
Vernieri C, Signorelli D, Galli G, Ganzinelli M, Moro M, Fabbri A, Tamborini E, Marabese M, Caiola E, Broggini M, Hollander L, Gallucci R, Vandoni G, Gavazzi C, Triulzi T, Colombo MP, Rizzo AM, Corsetto PA, Pruneri G, de Braud F, Sozzi G, Torri V, Garassino MC. Vernieri C, et al. Among authors: broggini m. Clin Lung Cancer. 2019 May;20(3):e413-e417. doi: 10.1016/j.cllc.2018.12.011. Epub 2018 Dec 19. Clin Lung Cancer. 2019. PMID: 30617039
LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors.
Caiola E, Iezzi A, Tomanelli M, Bonaldi E, Scagliotti A, Colombo M, Guffanti F, Micotti E, Garassino MC, Minoli L, Scanziani E, Broggini M, Marabese M. Caiola E, et al. Among authors: broggini m. J Thorac Oncol. 2020 Mar;15(3):360-370. doi: 10.1016/j.jtho.2019.10.009. Epub 2019 Oct 18. J Thorac Oncol. 2020. PMID: 31634668 Free article.
LKB1 Down-Modulation by miR-17 Identifies Patients With NSCLC Having Worse Prognosis Eligible for Energy-Stress-Based Treatments.
Borzi C, Ganzinelli M, Caiola E, Colombo M, Centonze G, Boeri M, Signorelli D, Caleca L, Rulli E, Busico A, Capone I, Pastorino U, Marabese M, Milione M, Broggini M, Garassino MC, Sozzi G, Moro M. Borzi C, et al. Among authors: broggini m. J Thorac Oncol. 2021 Aug;16(8):1298-1311. doi: 10.1016/j.jtho.2021.04.005. Epub 2021 Apr 19. J Thorac Oncol. 2021. PMID: 33887464 Free article.
EGFR mutations and EGFR tyrosine kinase inhibitors.
Torri V, Broggini M, Garassino MC. Torri V, et al. Among authors: broggini m. Lancet Oncol. 2015 Jul;16(7):746-8. doi: 10.1016/S1470-2045(15)00028-5. Epub 2015 Jun 4. Lancet Oncol. 2015. PMID: 26051233 No abstract available.
303 results