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Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change.
Dehkordi SR, Wong IT, Ni J, Luebeck J, Zhu K, Prasad G, Krockenberger L, Xu G, Chowdhury B, Rajkumar U, Caplin A, Muliaditan D, Coruh C, Jin Q, Turner K, Teo SX, Pang AWC, Alexandrov LB, Chua CEL, Furnari FB, Paulson TG, Law JA, Chang HY, Yue F, DasGupta R, Zhao J, Mischel PS, Bafna V. Dehkordi SR, et al. Among authors: xu g. bioRxiv [Preprint]. 2023 Dec 13:2023.12.12.571349. doi: 10.1101/2023.12.12.571349. bioRxiv. 2023. PMID: 38168210 Free PMC article. Preprint.
CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing.
Felgines L, Rymen B, Martins LM, Xu G, Matteoli C, Himber C, Zhou M, Eis J, Coruh C, Böhrer M, Kuhn L, Chicher J, Pandey V, Hammann P, Wohlschlegel J, Waltz F, Law JA, Blevins T. Felgines L, et al. Among authors: xu g. bioRxiv [Preprint]. 2023 Dec 26:2023.12.26.573199. doi: 10.1101/2023.12.26.573199. bioRxiv. 2023. Update in: Nat Commun. 2024 Nov 27;15(1):10298. doi: 10.1038/s41467-024-54268-0 PMID: 38234754 Free PMC article. Updated. Preprint.
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