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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.
Schröder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, Gauter F, Li X, Sigoillot F, Gleim S, Stachyra TM, Thomas JR, Begue D, Khoshouei M, Lefeuvre P, Andraos-Rey R, Chung B, Ma R, Pinch B, Hofmann A, Schirle M, Schmiedeberg N, Imbach P, Gorses D, Calkins K, Bauer-Probst B, Maschlej M, Niederst M, Maher R, Henault M, Alford J, Ahrne E, Tordella L, Hollingworth G, Thomä NH, Vulpetti A, Radimerski T, Holzer P, Carbonneau S, Thoma CR. Schröder M, et al. Among authors: begue d. Nat Commun. 2024 Jan 4;15(1):275. doi: 10.1038/s41467-023-44237-4. Nat Commun. 2024. PMID: 38177131 Free PMC article.
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Mutlu M, Schmidt I, Morrison AI, Goretzki B, Freuler F, Begue D, Simic O, Pythoud N, Ahrne E, Kapps S, Roest S, Bonenfant D, Jeanpierre D, Tran TT, Maher R, An S, Rietsch A, Nigsch F, Hofmann A, Reece-Hoyes J, Parker CN, Guerini D. Mutlu M, et al. Among authors: begue d. Nat Commun. 2024 May 29;15(1):4584. doi: 10.1038/s41467-024-48922-w. Nat Commun. 2024. PMID: 38811577 Free PMC article.
Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.
Schröder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, Gauter F, Li X, Sigoillot F, Gleim S, Stachyra TM, Thomas JR, Begue D, Khoshouei M, Lefeuvre P, Andraos-Rey R, Chung B, Ma R, Pinch B, Hofmann A, Schirle M, Schmiedeberg N, Imbach P, Gorses D, Calkins K, Bauer-Probst B, Maschlej M, Niederst M, Maher R, Henault M, Alford J, Ahrne E, Tordella L, Hollingworth G, Thomä NH, Vulpetti A, Radimerski T, Holzer P, Carbonneau S, Thoma CR. Schröder M, et al. Among authors: begue d. Nat Commun. 2024 Aug 19;15(1):7109. doi: 10.1038/s41467-024-51317-6. Nat Commun. 2024. PMID: 39160182 Free PMC article. No abstract available.
Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.
Apfel V, Begue D, Cordo' V, Holzer L, Martinuzzi L, Buhles A, Kerr G, Barbosa I, Naumann U, Piquet M, Ruddy D, Weiss A, Ferretti S, Almeida R, Bonenfant D, Tordella L, Galli GG. Apfel V, et al. Among authors: begue d. ACS Pharmacol Transl Sci. 2021 Jan 13;4(1):327-337. doi: 10.1021/acsptsci.0c00196. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615182 Free PMC article.
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin JM, DeJesus R, Kang Z, Antczak C, Begue D, Bonenfant D, Graff A, Genoud C, Reece-Hoyes JS, Russ C, Yang Z, Hoffman GR, Mueller M, Murphy LO, Xavier RJ, Nyfeler B. Moretti F, et al. Among authors: begue d. EMBO Rep. 2018 Sep;19(9):e45889. doi: 10.15252/embr.201845889. Epub 2018 Aug 20. EMBO Rep. 2018. PMID: 30126924 Free PMC article.
Haddon's POAV2 vs POAV theory for non-planar molecules.
Sabalot-Cuzzubbo J, Cresson N, Salvato Vallverdu G, Bégué D, Cresson J. Sabalot-Cuzzubbo J, et al. Among authors: begue d. J Chem Phys. 2023 Nov 7;159(17):174109. doi: 10.1063/5.0170800. J Chem Phys. 2023. PMID: 37933779
78 results