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USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms.
Koch I, Slovik M, Zhang Y, Liu B, Rennie M, Konz E, Cogne B, Daana M, Davids L, Diets IJ, Gold NB, Holtz AM, Isidor B, Mor-Shaked H, Neira Fresneda J, Niederhoffer KY, Nizon M, Pfundt R, Simon M, Stegmann A, Guillen Sacoto MJ, Wevers M, Barakat TS, Yanovsky-Dagan S, Atanassov BS, Toth R, Gao C, Bustos F, Harel T. Koch I, et al. Among authors: toth r. Life Sci Alliance. 2024 Jan 5;7(3):e202302258. doi: 10.26508/lsa.202302258. Print 2024 Mar. Life Sci Alliance. 2024. PMID: 38182161 Free PMC article.
Allosteric mechanism for site-specific ubiquitination of FANCD2.
Chaugule VK, Arkinson C, Rennie ML, Kämäräinen O, Toth R, Walden H. Chaugule VK, et al. Among authors: toth r. Nat Chem Biol. 2020 Mar;16(3):291-301. doi: 10.1038/s41589-019-0426-z. Epub 2019 Dec 23. Nat Chem Biol. 2020. PMID: 31873223 Free PMC article.
Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Rennie ML, Arkinson C, Chaugule VK, Toth R, Walden H. Rennie ML, et al. Among authors: toth r. Nat Struct Mol Biol. 2021 Apr;28(4):356-364. doi: 10.1038/s41594-021-00576-8. Epub 2021 Apr 1. Nat Struct Mol Biol. 2021. PMID: 33795880 Free article.
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.
Bustos F, Segarra-Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, Brandenburg L, Macartney TJ, Toth R, Hastie CJ, Moran J, Gourlay R, Varghese J, Soares RF, Montecino M, Findlay GM. Bustos F, et al. Among authors: toth r. Dev Cell. 2020 Dec 7;55(5):629-647.e7. doi: 10.1016/j.devcel.2020.09.025. Epub 2020 Oct 19. Dev Cell. 2020. PMID: 33080171 Free PMC article.
Structure-based design and characterization of Parkin-activating mutations.
Stevens MU, Croteau N, Eldeeb MA, Antico O, Zeng ZW, Toth R, Durcan TM, Springer W, Fon EA, Muqit MM, Trempe JF. Stevens MU, et al. Among authors: toth r. Life Sci Alliance. 2023 Mar 20;6(6):e202201419. doi: 10.26508/lsa.202201419. Print 2023 Jun. Life Sci Alliance. 2023. PMID: 36941054 Free PMC article.
425 results