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Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells.
Olmo-Fontánez AM, Scordo JM, Schami A, Garcia-Vilanova A, Pino PA, Hicks A, Mishra R, Jose Maselli D, Peters JI, Restrepo BI, Nargan K, Naidoo T, Clemens DL, Steyn AJC, Thacker VV, Turner J, Schlesinger LS, Torrelles JB. Olmo-Fontánez AM, et al. Among authors: torrelles jb. Mucosal Immunol. 2024 Apr;17(2):155-168. doi: 10.1016/j.mucimm.2024.01.001. Epub 2024 Jan 6. Mucosal Immunol. 2024. PMID: 38185331 Free PMC article.
Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents.
Zarkoob H, Allué-Guardia A, Chen YC, Jung O, Garcia-Vilanova A, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Yewdell J, Torrelles JB, Martinez-Sobrido L, Cherry S, Ferrer M, Lee EM. Zarkoob H, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2021 May 12:2021.05.11.443693. doi: 10.1101/2021.05.11.443693. bioRxiv. 2021. Update in: Commun Biol. 2022 Aug 12;5(1):810. doi: 10.1038/s42003-022-03753-7 PMID: 34013274 Free PMC article. Updated. Preprint.
Host- and age-dependent transcriptional changes in Mycobacterium tuberculosis cell envelope biosynthesis genes after exposure to human alveolar lining fluid.
Allué-Guardia A, Garcia-Vilanova A, M Olmo-Fontánez A, Peters J, Maselli DJ, Wang Y, Turner J, Schlesinger LS, Torrelles JB. Allué-Guardia A, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2021 Sep 20:2021.09.08.459334. doi: 10.1101/2021.09.08.459334. bioRxiv. 2021. Update in: Int J Mol Sci. 2022 Jan 17;23(2):983. doi: 10.3390/ijms23020983 PMID: 34580670 Free PMC article. Updated. Preprint.
A new tractable method for generating Human Alveolar Macrophage Like cells in vitro to study lung inflammatory processes and diseases.
Pahari S, Arnett E, Simper J, Azad A, Guerrero-Arguero I, Ye C, Zhang H, Cai H, Wang Y, Lai Z, Jarvis N, Lumbreras M, Maselli-Caceres DJ, Peters J, Torrelles JB, Martinez-Sobrido L, Schlesinger LS. Pahari S, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535806. doi: 10.1101/2023.04.05.535806. bioRxiv. 2023. Update in: mBio. 2023 Aug 31;14(4):e0083423. doi: 10.1128/mbio.00834-23 PMID: 37066199 Free PMC article. Updated. Preprint.
Exposure of Mycobacterium tuberculosis to human alveolar lining fluid shows temporal and strain-specific adaptation to the lung environment.
Allué-Guardia A, Garcia-Vilanova A, Schami AM, Olmo-Fontánez AM, Hicks A, Peters J, Maselli DJ, Wewers MD, Wang Y, Torrelles JB. Allué-Guardia A, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2023 Sep 28:2023.09.27.559381. doi: 10.1101/2023.09.27.559381. bioRxiv. 2023. PMID: 37808780 Free PMC article. Preprint.
Mitochondrial Transplantation promotes protective effector and memory CD4+ T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4+ T cells.
Headley CA, Gautam S, Olmo-Fontanez A, Garcia-Vilanova A, Dwivedi V, Schami A, Weintraub S, Tsao PS, Torrelles JB, Turner J. Headley CA, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2024 Jan 27:2024.01.24.577036. doi: 10.1101/2024.01.24.577036. bioRxiv. 2024. Update in: Adv Sci (Weinh). 2024 Sep;11(36):e2401077. doi: 10.1002/advs.202401077 PMID: 38328206 Free PMC article. Updated. Preprint.
Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.
Schami A, Islam MN, Wall M, Hicks A, Meredith R, Kreiswirth B, Mathema B, Belisle JT, Torrelles JB. Schami A, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2024 Apr 11:2024.04.10.588986. doi: 10.1101/2024.04.10.588986. bioRxiv. 2024. Update in: Sci Rep. 2024 Dec 28;14(1):30840. doi: 10.1038/s41598-024-81457-0 PMID: 38645029 Free PMC article. Updated. Preprint.
Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission.
Ye C, Park JG, Chiem K, Dravid P, Allué-Guardia A, Garcia-Vilanova A, Kapoor A, Walter MR, Kobie JJ, Plemper RK, Torrelles JB, Martinez-Sobrido L. Ye C, et al. Among authors: torrelles jb. bioRxiv [Preprint]. 2022 Mar 14:2022.03.13.484172. doi: 10.1101/2022.03.13.484172. bioRxiv. 2022. Update in: Microbiol Spectr. 2023 Jun 15;11(3):e0065323. doi: 10.1128/spectrum.00653-23 PMID: 35313573 Free PMC article. Updated. Preprint.
Replication kinetics, pathogenicity and virus-induced cellular responses of cattle-origin influenza A(H5N1) isolates from Texas, United States.
Mostafa A, Barre RS, Allué-Guardia A, Escobedo RA, Shivanna V, Rothan H, Castro EM, Ma Y, Cupic A, Jackson N, Bayoumi M, Torrelles JB, Ye C, García-Sastre A, Martinez-Sobrido L. Mostafa A, et al. Among authors: torrelles jb. Emerg Microbes Infect. 2025 Dec;14(1):2447614. doi: 10.1080/22221751.2024.2447614. Epub 2025 Jan 8. Emerg Microbes Infect. 2025. PMID: 39727152 Free PMC article.
138 results