Clark DS - Search Results

1

Enantio- and Diastereodivergent Cyclopropanation of Allenes by Directed Evolution of an Iridium-Containing Cytochrome.

Bloomer BJ, Joyner IA, Garcia-Borràs M, Hu DB, Garçon M, Quest A, Ugarte Montero C, Yu IF, Clark DS, Hartwig JF. Bloomer BJ, et al. Among authors: clark ds. J Am Chem Soc. 2024 Jan 24;146(3):1819-1824. doi: 10.1021/jacs.3c13011. Epub 2024 Jan 8. J Am Chem Soc. 2024. PMID: 38190322

2

Generation, Characterization, and Tunable Reactivity of Organometallic Fragments Bound to a Protein Ligand.

Key HM, Clark DS, Hartwig JF. Key HM, et al. Among authors: clark ds. J Am Chem Soc. 2015 Jul 1;137(25):8261-8. doi: 10.1021/jacs.5b04431. Epub 2015 Jun 23. J Am Chem Soc. 2015. PMID: 26020584 Free PMC article.

3

Abiological catalysis by artificial haem proteins containing noble metals in place of iron.

Key HM, Dydio P, Clark DS, Hartwig JF. Key HM, et al. Among authors: clark ds. Nature. 2016 Jun 23;534(7608):534-7. doi: 10.1038/nature17968. Epub 2016 Jun 13. Nature. 2016. PMID: 27296224 Free PMC article.

4

Chemoselective, Enzymatic C-H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor.

Dydio P, Key HM, Hayashi H, Clark DS, Hartwig JF. Dydio P, et al. Among authors: clark ds. J Am Chem Soc. 2017 Feb 8;139(5):1750-1753. doi: 10.1021/jacs.6b11410. Epub 2017 Jan 26. J Am Chem Soc. 2017. PMID: 28080030 Free article.

5

Beyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes.

Key HM, Dydio P, Liu Z, Rha JY, Nazarenko A, Seyedkazemi V, Clark DS, Hartwig JF. Key HM, et al. Among authors: clark ds. ACS Cent Sci. 2017 Apr 26;3(4):302-308. doi: 10.1021/acscentsci.6b00391. Epub 2017 Apr 1. ACS Cent Sci. 2017. PMID: 28470047 Free PMC article.

6

Site-Selective Functionalization of (sp³ )C-H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor.

Gu Y, Natoli SN, Liu Z, Clark DS, Hartwig JF. Gu Y, et al. Among authors: clark ds. Angew Chem Int Ed Engl. 2019 Sep 23;58(39):13954-13960. doi: 10.1002/anie.201907460. Epub 2019 Aug 21. Angew Chem Int Ed Engl. 2019. PMID: 31356719 Free PMC article. Review.

7

Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride.

Ji P, Park J, Gu Y, Clark DS, Hartwig JF. Ji P, et al. Among authors: clark ds. Nat Chem. 2021 Apr;13(4):312-318. doi: 10.1038/s41557-020-00633-7. Epub 2021 Feb 18. Nat Chem. 2021. PMID: 33603222 Free PMC article.

8

Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme.

Huang J, Liu Z, Bloomer BJ, Clark DS, Mukhopadhyay A, Keasling JD, Hartwig JF. Huang J, et al. Among authors: clark ds. Nat Chem. 2021 Dec;13(12):1186-1191. doi: 10.1038/s41557-021-00801-3. Epub 2021 Oct 14. Nat Chem. 2021. PMID: 34650235 Free PMC article.

9

Directed Evolution of Artificial Metalloenzymes in Whole Cells.

Gu Y, Bloomer BJ, Liu Z, Chen R, Clark DS, Hartwig JF. Gu Y, et al. Among authors: clark ds. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202110519. doi: 10.1002/anie.202110519. Epub 2021 Dec 22. Angew Chem Int Ed Engl. 2022. PMID: 34766418 Free PMC article.

10

Assembly and Evolution of Artificial Metalloenzymes within E. coli Nissle 1917 for Enantioselective and Site-Selective Functionalization of C─H and C═C Bonds.

Liu Z, Huang J, Gu Y, Clark DS, Mukhopadhyay A, Keasling JD, Hartwig JF. Liu Z, et al. Among authors: clark ds. J Am Chem Soc. 2022 Jan 19;144(2):883-890. doi: 10.1021/jacs.1c10975. Epub 2022 Jan 5. J Am Chem Soc. 2022. PMID: 34985270 Free PMC article.

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