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An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer.
Eur J Med Chem. 2024 Feb 5;265:116114. doi: 10.1016/j.ejmech.2023.116114. Epub 2023 Dec 31.
Eur J Med Chem. 2024.
PMID: 38194775
Free article.
Novel Insights into RAD52's Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies.
Balboni B, Rinaldi F, Previtali V, Ciamarone A, Girotto S, Cavalli A.
Balboni B, et al. Among authors: ciamarone a.
Cancers (Basel). 2023 Mar 17;15(6):1817. doi: 10.3390/cancers15061817.
Cancers (Basel). 2023.
PMID: 36980703
Free PMC article.
Review.
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New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives.
Previtali V, Bagnolini G, Ciamarone A, Ferrandi G, Rinaldi F, Myers SH, Roberti M, Cavalli A.
Previtali V, et al. Among authors: ciamarone a.
J Med Chem. 2024 Jul 25;67(14):11488-11521. doi: 10.1021/acs.jmedchem.4c00113. Epub 2024 Jul 2.
J Med Chem. 2024.
PMID: 38955347
Free PMC article.
Review.
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