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PKN2 is a dependency of the mesenchymal-like cancer cell state.
Killarney ST, Mesa G, Washart R, Mayro B, Dillon K, Wardell SE, Newlin M, Lu M, Abu Rmaileh A, Liu N, McDonnell DP, Pendergast AM, Wood KC. Killarney ST, et al. Among authors: abu rmaileh a. Cancer Discov. 2024 Nov 19. doi: 10.1158/2159-8290.CD-24-0928. Online ahead of print. Cancer Discov. 2024. PMID: 39560431
The exostosin glycosyltransferase 1/STAT3 axis is a driver of breast cancer aggressiveness.
Solaimuthu B, Khatib A, Tanna M, Karmi A, Hayashi A, Abu Rmaileh A, Lichtenstein M, Takoe S, Jolly MK, Shaul YD. Solaimuthu B, et al. Among authors: abu rmaileh a. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2316733121. doi: 10.1073/pnas.2316733121. Epub 2024 Jan 12. Proc Natl Acad Sci U S A. 2024. PMID: 38215181 Free PMC article.
DPYSL2 interacts with JAK1 to mediate breast cancer cell migration.
Abu Rmaileh A, Solaimuthu B, Khatib A, Lavi S, Tanna M, Hayashi A, Ben Yosef M, Lichtenstein M, Pillar N, Shaul YD. Abu Rmaileh A, et al. J Cell Biol. 2022 Jul 4;221(7):e202106078. doi: 10.1083/jcb.202106078. Epub 2022 May 16. J Cell Biol. 2022. PMID: 35575798 Free PMC article.
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Khatib A, Solaimuthu B, Ben Yosef M, Abu Rmaileh A, Tanna M, Oren G, Schlesinger Frisch M, Axelrod JH, Lichtenstein M, Shaul YD. Khatib A, et al. Among authors: abu rmaileh a. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21420-21431. doi: 10.1073/pnas.2010275117. Epub 2020 Aug 18. Proc Natl Acad Sci U S A. 2020. PMID: 32817494 Free PMC article.