Glaab WE - Search Results

1

A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.

Aslamkhan AG, Michna L, Podtelezhnikov A, Vlasakova K, Suemizu H, Ohnishi Y, Liu L, Lane P, Xu Q, Kuhls MC, Wang Z, Pacchione S, Erdos Z, Tracy RW, Koeplinger K, Muniappa N, Valentine J, Galijatovic-Idrizbegovic A, Glaab WE, Sistare FD, Lebron J. Aslamkhan AG, et al. Among authors: glaab we. Toxicol Res (Camb). 2024 Jan 11;13(1):tfad120. doi: 10.1093/toxres/tfad120. eCollection 2024 Feb. Toxicol Res (Camb). 2024. PMID: 38223529

2

Response of Novel Skeletal Muscle Biomarkers in Dogs to Drug-Induced Skeletal Muscle Injury or Sustained Endurance Exercise.

Vlasakova K, Lane P, Michna L, Muniappa N, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: glaab we. Toxicol Sci. 2017 Apr 1;156(2):422-427. doi: 10.1093/toxsci/kfw262. Toxicol Sci. 2017. PMID: 28115646

3

AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats.

Qin C, Aslamkhan AG, Pearson K, Tanis KQ, Podtelezhnikov A, Frank E, Pacchione S, Pippert T, Glaab WE, Sistare FD. Qin C, et al. Among authors: glaab we. Toxicol Sci. 2019 Sep 1;171(1):46-55. doi: 10.1093/toxsci/kfz125. Toxicol Sci. 2019. PMID: 31127949

4

Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia.

Gu YZ, Vlasakova K, Darbes J, Wang E, Ferraro J, Glaab WE, Sistare FD. Gu YZ, et al. Among authors: glaab we. Toxicology. 2020 Jun;439:152462. doi: 10.1016/j.tox.2020.152462. Epub 2020 Apr 27. Toxicology. 2020. PMID: 32348786

5

Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates.

Vlasakova K, Troth SP, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: glaab we. Toxicol Pathol. 2020 Jul;48(5):633-648. doi: 10.1177/0192623320932159. Toxicol Pathol. 2020. PMID: 32633702

6

Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats.

Erdos Z, Pearson K, Goedken M, Menzel K, Sistare FD, Glaab WE, Saldutti LP. Erdos Z, et al. Among authors: glaab we. Birth Defects Res B Dev Reprod Toxicol. 2013 Feb;98(1):41-53. doi: 10.1002/bdrb.21035. Epub 2013 Jan 24. Birth Defects Res B Dev Reprod Toxicol. 2013. PMID: 23348767

7

Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies.

Vlasakova K, Erdos Z, Troth SP, McNulty K, Chapeau-Campredon V, Mokrzycki N, Muniappa N, Gu YZ, Holder D, Bailey WJ, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: glaab we. Toxicol Sci. 2014 Mar;138(1):3-20. doi: 10.1093/toxsci/kft330. Epub 2013 Dec 21. Toxicol Sci. 2014. PMID: 24361871

8

A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury.

Bailey WJ, Barnum JE, Erdos Z, LaFranco-Scheuch L, Lane P, Vlasakova K, Sistare FD, Glaab WE. Bailey WJ, et al. Among authors: glaab we. Toxicol Sci. 2019 Mar 1;168(1):110-125. doi: 10.1093/toxsci/kfy282. Toxicol Sci. 2019. PMID: 30496518

9

Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities.

Podtelezhnikov AA, Monroe JJ, Aslamkhan AG, Pearson K, Qin C, Tamburino AM, Loboda AP, Glaab WE, Sistare FD, Tanis KQ. Podtelezhnikov AA, et al. Among authors: glaab we. Toxicol Sci. 2020 May 1;175(1):98-112. doi: 10.1093/toxsci/kfaa026. Toxicol Sci. 2020. PMID: 32119089

10

Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats.

Glaab WE, Holder D, He YD, Bailey WJ, Gerhold DL, Beare C, Erdos Z, Lane P, Michna L, Muniappa N, Lawrence JW, Tanis KQ, Sina JF, Skopek TR, Sistare FD. Glaab WE, et al. Toxicol Sci. 2021 May 27;181(2):148-159. doi: 10.1093/toxsci/kfab038. Toxicol Sci. 2021. PMID: 33837425

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