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A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.
Papa A, Del Rivero Morfin PJ, Chen BX, Yang L, Katchman AN, Zakharov SI, Liu G, Bohnen MS, Zheng V, Katz M, Subramaniam S, Hirsch JA, Weiss S, Dascal N, Karlin A, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO. Papa A, et al. Among authors: dascal n. J Clin Invest. 2024 Jan 16;134(5):e176943. doi: 10.1172/JCI176943. J Clin Invest. 2024. PMID: 38227371 Free PMC article.
Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.
Colombo S, Reddy HP, Petri S, Williams DJ, Shalomov B, Dhindsa RS, Gelfman S, Krizay D, Bera AK, Yang M, Peng Y, Makinson CD, Boland MJ, Frankel WN, Goldstein DB, Dascal N. Colombo S, et al. Among authors: dascal n. Front Cell Neurosci. 2023 May 18;17:1175895. doi: 10.3389/fncel.2023.1175895. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37275776 Free PMC article.
Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation.
Oz S, Keren-Raifman T, Sharon T, Subramaniam S, Pallien T, Katz M, Tsemakhovich V, Sholokh A, Watad B, Tripathy DR, Sasson G, Chomsky-Hecht O, Vysochek L, Schulz-Christian M, Fecher-Trost C, Zühlke K, Bertinetti D, Herberg FW, Flockerzi V, Hirsch JA, Klussmann E, Weiss S, Dascal N. Oz S, et al. Among authors: dascal n. BMC Biol. 2024 Nov 28;22(1):276. doi: 10.1186/s12915-024-02076-9. BMC Biol. 2024. PMID: 39609812 Free PMC article.
A novel small-molecule selective activator of homomeric GIRK4 channels.
Cui M, Xu K, Gada KD, Shalomov B, Ban M, Eptaminitaki GC, Kawano T, Plant LD, Dascal N, Logothetis DE. Cui M, et al. Among authors: dascal n. J Biol Chem. 2022 Jun;298(6):102009. doi: 10.1016/j.jbc.2022.102009. Epub 2022 May 4. J Biol Chem. 2022. PMID: 35525275 Free PMC article.
Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels.
Reddy HP, Yakubovich D, Keren-Raifman T, Tabak G, Tsemakhovich VA, Pedersen MH, Shalomov B, Colombo S, Goldstein DB, Javitch JA, Bera AK, Dascal N. Reddy HP, et al. Among authors: dascal n. iScience. 2021 Aug 21;24(9):103018. doi: 10.1016/j.isci.2021.103018. eCollection 2021 Sep 24. iScience. 2021. PMID: 34522861 Free PMC article.
146 results