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NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.
Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. Porter LC, et al. Among authors: sasaki y. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E520-E530. doi: 10.1152/ajpendo.00057.2018. Epub 2018 Apr 10. Am J Physiol Endocrinol Metab. 2018. PMID: 29634313 Free PMC article.
Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging.
Qi N, Franczyk MP, Yamaguchi S, Kojima D, Hayashi K, Satoh A, Ogiso N, Kanda T, Sasaki Y, Finck BN, DeBosch BJ, Yoshino J. Qi N, et al. Among authors: sasaki y. Am J Physiol Endocrinol Metab. 2024 Jul 1;327(1):E81-E88. doi: 10.1152/ajpendo.00313.2023. Epub 2024 May 29. Am J Physiol Endocrinol Metab. 2024. PMID: 38809511
Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism.
Yamaguchi S, Kojima D, Iqbal T, Kosugi S, Franczyk MP, Qi N, Sasaki Y, Yaku K, Kaneko K, Kinouchi K, Itoh H, Hayashi K, Nakagawa T, Yoshino J. Yamaguchi S, et al. Among authors: sasaki y. Biochem Biophys Res Commun. 2023 Sep 24;674:162-169. doi: 10.1016/j.bbrc.2023.07.007. Epub 2023 Jul 4. Biochem Biophys Res Commun. 2023. PMID: 37421924
Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility.
Franczyk MP, Qi N, Stromsdorfer KL, Li C, Yamaguchi S, Itoh H, Yoshino M, Sasaki Y, Brookheart RT, Finck BN, DeBosch BJ, Klein S, Yoshino J. Franczyk MP, et al. Among authors: sasaki y. Endocrinology. 2021 Mar 1;162(3):bqab006. doi: 10.1210/endocr/bqab006. Endocrinology. 2021. PMID: 33543238 Free PMC article.
6,162 results