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First-in-Human Phase I Trial to Assess the Safety and Immunogenicity of an Orf Virus-Based COVID-19 Vaccine Booster.
Esen M, Fischer-Herr J, Gabor JJ, Gaile JM, Fleischmann WA, Smeenk GW, de Moraes RA, Bélard S, Calle CL, Woldearegai TG, Egger-Adam D, Haug V, Metz C, Reguzova A, Löffler MW, Balode B, Matthies LC, Ramharter M, Amann R, Kremsner PG. Esen M, et al. Among authors: amann r. Vaccines (Basel). 2024 Nov 18;12(11):1288. doi: 10.3390/vaccines12111288. Vaccines (Basel). 2024. PMID: 39591190 Free PMC article.
A multiantigenic Orf virus-based vaccine efficiently protects hamsters and nonhuman primates against SARS-CoV-2.
Reguzova A, Müller M, Pagallies F, Burri D, Salomon F, Rziha HJ, Bittner-Schrader Z, Verstrepen BE, Böszörményi KP, Verschoor EJ, Gerhauser I, Elbers K, Esen M, Manenti A, Monti M, Rammensee HG, Derouazi M, Löffler MW, Amann R. Reguzova A, et al. Among authors: amann r. NPJ Vaccines. 2024 Oct 16;9(1):191. doi: 10.1038/s41541-024-00981-2. NPJ Vaccines. 2024. PMID: 39414789 Free PMC article.
A novel orf virus vector-based COVID-19 booster vaccine shows cross-neutralizing activity in the absence of anti-vector neutralizing immunity.
Klinkardt U, Schunk M, Ervin J, Schindler C, Sugimoto D, Rankin B, Amann R, Monti M, Kutschenko A, Schumacher C, Huber K, Zeder A, Heikkila N, Didierlaurent AM, Schwarz SE, Derouazi M. Klinkardt U, et al. Among authors: amann r. Hum Vaccin Immunother. 2024 Dec 31;20(1):2410574. doi: 10.1080/21645515.2024.2410574. Epub 2024 Oct 14. Hum Vaccin Immunother. 2024. PMID: 39397784 Free PMC article. Clinical Trial.
672 results