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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
Yang Y, Yeh SH, Madireddi S, Matochko WL, Gu C, Pacheco Sanchez P, Ultsch M, De Leon Boenig G, Harris SF, Leonard B, Scales SJ, Zhu JW, Christensen E, Hang JQ, Brezski RJ, Marsters S, Ashkenazi A, Sukumaran S, Chiu H, Cubas R, Kim JM, Lazar GA. Yang Y, et al. Among authors: leonard b. MAbs. 2019 Aug/Sep;11(6):996-1011. doi: 10.1080/19420862.2019.1625662. Epub 2019 Jun 20. MAbs. 2019. PMID: 31156033 Free PMC article.
Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics.
Darwish M, Shatz W, Leonard B, Loyet K, Barrett K, Wong JL, Li H, Abraham R, Lin M, Franke Y, Tam C, Mortara K, Zilberleyb I, Blanchette C. Darwish M, et al. Among authors: leonard b. Bioconjug Chem. 2020 Aug 19;31(8):1995-2007. doi: 10.1021/acs.bioconjchem.0c00349. Epub 2020 Aug 5. Bioconjug Chem. 2020. PMID: 32701261
Targeted IgMs agonize ocular targets with extended vitreal exposure.
Chen Y, Paluch M, Zorn JA, Rajan S, Leonard B, Estevez A, Brady J, Chiu H, Phung W, Famili A, Yan M, Ciferri C, Matsumoto ML, Lazar GA, Crowell S, Hass P, Agard NJ. Chen Y, et al. Among authors: leonard b. MAbs. 2020 Jan-Dec;12(1):1818436. doi: 10.1080/19420862.2020.1818436. MAbs. 2020. PMID: 32936727 Free PMC article.
Antibody interfaces revealed through structural mining.
Yin Y, Romei MG, Sankar K, Pal LR, Hoi KH, Yang Y, Leonard B, De Leon Boenig G, Kumar N, Matsumoto M, Payandeh J, Harris SF, Moult J, Lazar GA. Yin Y, et al. Among authors: leonard b. Comput Struct Biotechnol J. 2022 Aug 31;20:4952-4968. doi: 10.1016/j.csbj.2022.08.048. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36147680 Free PMC article.
Adapting Ferritin, a Naturally Occurring Protein Cage, to Modulate Intrinsic Agonism of OX40.
Shatz-Binder W, Azumaya CM, Leonard B, Vuong I, Sudhamsu J, Rohou A, Liu P, Sandoval W, Bol K, Izadi S, Holder PG, Blanchette C, Perozzo R, Kelley RF, Kalia Y. Shatz-Binder W, et al. Among authors: leonard b. Bioconjug Chem. 2024 May 15;35(5):593-603. doi: 10.1021/acs.bioconjchem.4c00020. Epub 2024 Apr 9. Bioconjug Chem. 2024. PMID: 38592684 Free PMC article.
845 results