Mai A - Search Results

1

Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.

Pannek M, Alhalabi Z, Tomaselli D, Menna M, Fiorentino F, Robaa D, Weyand M, Puhlmann M, Tomassi S, Barreca F, Tafani M, Zaganjor E, Haigis MC, Sippl W, Rotili D, Mai A, Steegborn C. Pannek M, et al. Among authors: mai a. J Med Chem. 2024 Feb 8;67(3):1843-1860. doi: 10.1021/acs.jmedchem.3c01496. Epub 2024 Jan 22. J Med Chem. 2024. PMID: 38253001

2

Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R. Mai A, et al. J Med Chem. 2001 Aug 2;44(16):2544-54. doi: 10.1021/jm010853h. J Med Chem. 2001. PMID: 11472208

5-Alkyl-2-(alkylthio)-6-(2,6-difluorobenzyl)-3,4-dihydropyrimidin-4(3H)-ones (S-DABOs, 2) have been recently described as a new class of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) active at nanomolar concentrat …

5-Alkyl-2-(alkylthio)-6-(2,6-difluorobenzyl)-3,4-dihydropyrimidin-4(3H)-ones (S-DABOs, 2) have been recently described as a new class …

3

Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.

Mai A, Massa S, Pezzi R, Rotili D, Loidl P, Brosch G. Mai A, et al. J Med Chem. 2003 Nov 6;46(23):4826-9. doi: 10.1021/jm034167p. J Med Chem. 2003. PMID: 14584932

4

Histone deacetylation in epigenetics: an attractive target for anticancer therapy.

Mai A, Massa S, Rotili D, Cerbara I, Valente S, Pezzi R, Simeoni S, Ragno R. Mai A, et al. Med Res Rev. 2005 May;25(3):261-309. doi: 10.1002/med.20024. Med Res Rev. 2005. PMID: 15717297 Review.

5

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

Mai A, Massa S, Pezzi R, Simeoni S, Rotili D, Nebbioso A, Scognamiglio A, Altucci L, Loidl P, Brosch G. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53. doi: 10.1021/jm049002a. J Med Chem. 2005. PMID: 15857140

6

A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast.

Ornaghi P, Rotili D, Sbardella G, Mai A, Filetici P. Ornaghi P, et al. Among authors: mai a. Biochem Pharmacol. 2005 Sep 15;70(6):911-7. doi: 10.1016/j.bcp.2005.06.013. Biochem Pharmacol. 2005. PMID: 16043126

7

Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates.

Mai A, Massa S, Rotili D, Pezzi R, Bottoni P, Scatena R, Meraner J, Brosch G. Mai A, et al. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4656-61. doi: 10.1016/j.bmcl.2005.07.081. Bioorg Med Chem Lett. 2005. PMID: 16165353

8

6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase.

Bartolini S, Mai A, Artico M, Paesano N, Rotili D, Spadafora C, Sbardella G. Bartolini S, et al. Among authors: mai a. J Med Chem. 2005 Nov 3;48(22):6776-8. doi: 10.1021/jm0507330. J Med Chem. 2005. PMID: 16250634

9

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. Mai A, et al. J Med Chem. 2005 Dec 1;48(24):7789-95. doi: 10.1021/jm050100l. J Med Chem. 2005. PMID: 16302818

10

Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.

Mai A, Massa S, Rotili D, Simeoni S, Ragno R, Botta G, Nebbioso A, Miceli M, Altucci L, Brosch G. Mai A, et al. J Med Chem. 2006 Oct 5;49(20):6046-56. doi: 10.1021/jm0605536. J Med Chem. 2006. PMID: 17004718

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