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In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.
Dureja C, Rutherford JT, Pavel FB, Norseeda K, Prah I, Sun D, Hevener KE, Hurdle JG. Dureja C, et al. Among authors: hurdle jg. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0122223. doi: 10.1128/aac.01222-23. Epub 2024 Jan 24. Antimicrob Agents Chemother. 2024. PMID: 38265216 Free PMC article.
Bacterial persister cells tackled.
Hurdle JG, Deshpande A. Hurdle JG, et al. Nature. 2018 Apr 5;556(7699):40-41. doi: 10.1038/d41586-018-03440-w. Nature. 2018. PMID: 29620744 No abstract available.
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ. Lee RE, et al. Among authors: hurdle jg. Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26. Nat Med. 2014. PMID: 24464186 Free PMC article.
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
Feng L, Maddox MM, Alam MZ, Tsutsumi LS, Narula G, Bruhn DF, Wu X, Sandhaus S, Lee RB, Simmons CJ, Tse-Dinh YC, Hurdle JG, Lee RE, Sun D. Feng L, et al. Among authors: hurdle jg. J Med Chem. 2014 Oct 23;57(20):8398-420. doi: 10.1021/jm500853v. Epub 2014 Oct 7. J Med Chem. 2014. PMID: 25238443 Free PMC article.
61 results