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Utility of in vivo metabolomics to support read-across for UVCB substances under REACH.
Kamp H, Kocabas NA, Faulhammer F, Synhaeve N, Rushton E, Flick B, Giri V, Sperber S, Higgins LG, Penman MG, van Ravenzwaay B, Rooseboom M. Kamp H, et al. Among authors: higgins lg. Arch Toxicol. 2024 Mar;98(3):755-768. doi: 10.1007/s00204-023-03638-6. Epub 2024 Jan 24. Arch Toxicol. 2024. PMID: 38265474 Free PMC article.
The short-term toxicity and metabolome of dicyclopentadiene.
van Ravenzwaay B, Kocabas NA, Faulhammer F, Flick B, Giri V, Sperber S, Penman MG, Higgins LG, Kamp H, Rooseboom M. van Ravenzwaay B, et al. Among authors: higgins lg. Toxicol Lett. 2024 Mar;393:57-68. doi: 10.1016/j.toxlet.2024.01.005. Epub 2024 Jan 12. Toxicol Lett. 2024. PMID: 38219808 Free article.
The short-term toxicity and metabolome of Benzene.
Faulhammer F, van Ravenzwaay B, Schnatter AR, Rooseboom M, Kamp H, Flick B, Giri V, Sperber S, Higgins LG, Penman MG, Kocabas NA. Faulhammer F, et al. Among authors: higgins lg. Toxicol Lett. 2024 Oct;400:58-70. doi: 10.1016/j.toxlet.2024.07.913. Epub 2024 Jul 31. Toxicol Lett. 2024. PMID: 39094914 Free article.
Xylene: weight of evidence approach case study to determine the need for an extended one generation reproductive study with a developmental neurotoxicity animal cohort.
Faulhammer F, Rooseboom M, Kocabas NA, Arts JHE, Cordova A, Freeman E, Higgins LG, Nahar M, Richmond E, Schneider S, Morris-Schaffer K. Faulhammer F, et al. Among authors: higgins lg. Crit Rev Toxicol. 2024 Nov;54(10):925-952. doi: 10.1080/10408444.2024.2413073. Epub 2024 Nov 12. Crit Rev Toxicol. 2024. PMID: 39530411 Free article. Review.
Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.
Price RJ, Scott MP, Cantrill C, Higgins LG, Moreau M, Yoon M, Clewell HJ, Creek MR, Osimitz TG, Houston JB, Lake BG. Price RJ, et al. Among authors: higgins lg. Xenobiotica. 2021 Jan;51(1):40-50. doi: 10.1080/00498254.2020.1807075. Epub 2020 Aug 26. Xenobiotica. 2021. PMID: 32757971
Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Nudischer R, Renggli K, Bertinetti-Lapatki C, Hoflack JC, Flint N, Sewing S, Pedersen L, Schadt S, Higgins LG, Vardy A, Lenz B, Gand L, Boess F, Elcombe BM, Hierlemann A, Roth AB. Nudischer R, et al. Among authors: higgins lg. Toxicol Sci. 2020 Aug 1;176(2):329-342. doi: 10.1093/toxsci/kfaa076. Toxicol Sci. 2020. PMID: 32458970
35 results