Qing L - Search Results

1

Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability.

Xu J, Zhao A, Chen D, Wang J, Ma J, Qing L, Li Y, Fang H, He H, Pan W, Zhang S. Xu J, et al. Among authors: qing l. Eur J Med Chem. 2024 Feb 15;266:116160. doi: 10.1016/j.ejmech.2024.116160. Epub 2024 Jan 18. Eur J Med Chem. 2024. PMID: 38277917

2

Targeted Recruitment and Degradation of Estrogen Receptor α by Photothermal Polydopamine Nanoparticles for Breast Tumor Ablation.

Zhang Y, Ding X, Xie F, Gao M, Qiu J, Wang Z, Qing L, Yan J, Peng N, Li Y, Xu J, Cai Q, Jin Y, Jiao Y, Liu Y, He H, Zhang S. Zhang Y, et al. Among authors: qing l. Adv Healthc Mater. 2022 Oct;11(19):e2200960. doi: 10.1002/adhm.202200960. Epub 2022 Jul 19. Adv Healthc Mater. 2022. PMID: 35833876

3

Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability.

Zhang S, Qing L, Wang Z, Zhang Y, Li Y, Fang H, Liu Y, He H. Zhang S, et al. Among authors: qing l. J Med Chem. 2023 Apr 13;66(7):4849-4867. doi: 10.1021/acs.jmedchem.2c02006. Epub 2023 Mar 24. J Med Chem. 2023. PMID: 36961373

4

Design of Orally-bioavailable Tetra-cyclic phthalazine SOS1 inhibitors with high selectivity against EGFR.

He H, Chen R, Wang Z, Qing L, Zhang Y, Liu Y, Pan W, Fang H, Zhang S. He H, et al. Among authors: qing l. Bioorg Chem. 2023 Jul;136:106536. doi: 10.1016/j.bioorg.2023.106536. Epub 2023 Apr 10. Bioorg Chem. 2023. PMID: 37054529

5

Exploring the structural-activity relationship of hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]oxazine derivatives as potent and orally-bioavailable PARP7 inhibitors.

Zhang S, Zhang Y, Wang Z, Qing L, Fu S, Xu J, Li Y, Fang H, He H. Zhang S, et al. Among authors: qing l. Eur J Med Chem. 2023 Dec 5;261:115836. doi: 10.1016/j.ejmech.2023.115836. Epub 2023 Oct 8. Eur J Med Chem. 2023. PMID: 37826932

6

Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis.

He H, Wang Z, Peng X, Qing L, Zhang Y, Fu S, Xu J, Li Y, Zhang S. He H, et al. Among authors: qing l. J Med Chem. 2024 Jan 11;67(1):543-554. doi: 10.1021/acs.jmedchem.3c01770. Epub 2024 Jan 2. J Med Chem. 2024. PMID: 38166392

7

Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations.

Qing L, Cheng Z, Xu J, Wang Z, Li Y, Gauthier M, Zhang S, He H. Qing L, et al. Eur J Med Chem. 2025 Jan 15;282:117065. doi: 10.1016/j.ejmech.2024.117065. Epub 2024 Nov 17. Eur J Med Chem. 2025. PMID: 39580914

8

Discovery of D-Ring-Contracted Artemisinin as a Potent Hydrophobic Tag for Targeted Protein Degradation.

Qing L, Yu Q, Wang C, Lu X, Yang Y, Chen X, Li X, Min J, Pan W, He H, Zhong H, Zhang S. Qing L, et al. J Med Chem. 2025 Jan 2. doi: 10.1021/acs.jmedchem.4c02269. Online ahead of print. J Med Chem. 2025. PMID: 39748630

9

A comprehensive evaluation of the quality of Bu Shen Jian Gu oral liquid based on multi-indicator component quantification and chemical pattern recognition.

Qing L, Xie X, Deng Q, Liang J, Wu Y, Wei Y, Li F, Pan Z, Li Y. Qing L, et al. Anal Methods. 2025 Jan 21. doi: 10.1039/d4ay01828a. Online ahead of print. Anal Methods. 2025. PMID: 39834230

10

Development and Validation of a Highly Sensitive Isotope-Coded Equivalent Reporter Ion Assay for the Semi-Quantification of Isocoumarins in Complex Matrices.

Huang XF, Liang PY, Yin XD, Hou YC, Wang TT, Li RW, Zhang Z, Yao X, Luo P, Qing LS. Huang XF, et al. Among authors: qing ls. Anal Chem. 2025 Jan 16. doi: 10.1021/acs.analchem.4c05069. Online ahead of print. Anal Chem. 2025. PMID: 39818760

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