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Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment.
Bendtsen SK, Perez-Penco M, Hübbe ML, Martinenaite E, Orebo Holmström M, Weis-Banke SE, Grønne Dahlager Jørgensen N, Jørgensen MA, Munir Ahmad S, Jensen KM, Friese C, Lundsager MT, Johansen AZ, Carretta M, Ødum N, Met Ö, Svane IM, Madsen DH, Andersen MH. Bendtsen SK, et al. Among authors: orebo holmstrom m. Oncoimmunology. 2022 Jan 27;11(1):2026020. doi: 10.1080/2162402X.2022.2026020. eCollection 2022. Oncoimmunology. 2022. PMID: 35111385 Free PMC article.
An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma.
Klausen U, Grønne Dahlager Jørgensen N, Grauslund JH, Munir Ahmad S, Gang AO, Martinenaite E, Weis-Banke SE, Breinholt MF, Novotny GW, Kjeldsen JW, Orebo Holmström M, Pedersen LB, Poulsen CB, Hansen PB, Met Ö, Svane IM, Niemann CU, Pedersen LM, Andersen MH. Klausen U, et al. Among authors: orebo holmstrom m. Oncoimmunology. 2021 Sep 25;10(1):1975889. doi: 10.1080/2162402X.2021.1975889. eCollection 2021. Oncoimmunology. 2021. PMID: 38283034 Free PMC article.
Frequent adaptive immune responses against arginase-1.
Martinenaite E, Mortensen REJ, Hansen M, Orebo Holmström M, Munir Ahmad S, Grønne Dahlager Jørgensen N, Met Ö, Donia M, Svane IM, Andersen MH. Martinenaite E, et al. Among authors: orebo holmstrom m. Oncoimmunology. 2017 Dec 26;7(3):e1404215. doi: 10.1080/2162402X.2017.1404215. eCollection 2018. Oncoimmunology. 2017. PMID: 29399404 Free PMC article.