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Concentration-QTc Relationship from a Single Ascending Dose Study of ANAVEX3-71, a Novel Sigma-1 Receptor and Allosteric M1 Muscarinic Receptor Agonist in Development for the Treatment of Frontotemporal Dementia, Schizophrenia, and Alzheimer's Disease.
Fadiran EO, Hammond E, Tran J, Xue H, Chen J, Kaufmann WE, Missling CU, Darpo B. Fadiran EO, et al. Among authors: darpo b. Clin Pharmacol Drug Dev. 2023 Sep;12(9):888-901. doi: 10.1002/cpdd.1303. Epub 2023 Jul 28. Clin Pharmacol Drug Dev. 2023. PMID: 37515316
Relacorilant, a Selective Glucocorticoid Receptor Modulator in Development for the Treatment of Patients With Cushing Syndrome, Does Not Cause Prolongation of the Cardiac QT Interval.
Donegan DM, Pivonello R, Stigliano A, Lardo P, Kearney T, Mezősi E, Ghigo E, Giordano R, Mariash CN, Feelders RA, Donaldson K, Darpo B, Xue H, Custodio JM, Hand AL, Moraitis AG. Donegan DM, et al. Among authors: darpo b. Endocr Pract. 2024 Jan;30(1):11-18. doi: 10.1016/j.eprac.2023.09.011. Epub 2023 Oct 5. Endocr Pract. 2024. PMID: 37805100 Free article.
Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Hopkins SC, Toongsuwan S, Corriveau TJ, Watanabe T, Tsushima Y, Asada T, Lew R, Shi L, Zann V, Snowden TJ, van der Graaf PH, Darpo B, Searle GE, Rabiner EA, Wilding I, Szabo ST, Galluppi GR, Koblan KS. Hopkins SC, et al. Among authors: darpo b. Clin Pharmacol Ther. 2024 Aug;116(2):460-470. doi: 10.1002/cpt.3311. Epub 2024 May 31. Clin Pharmacol Ther. 2024. PMID: 38822554
132 results