Detwiler TJ - Search Results

1

Performance of biomarkers NF-L, NSE, Tau and GFAP in blood and cerebrospinal fluid in rat for the detection of nervous system injury.

Vlasakova K, Tsuchiya T, Garfinkel IN, Ruth MP, Tyszkiewicz C, Detwiler TJ, Somps CJ, Di Cesare Mannelli L, Glaab WE. Vlasakova K, et al. Among authors: detwiler tj. Front Neurosci. 2024 Jan 16;17:1285359. doi: 10.3389/fnins.2023.1285359. eCollection 2023. Front Neurosci. 2024. PMID: 38292901 Free PMC article.

2

A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis.

Hotek JC, Detwiler TJ, Chirinos JA, Regan CP. Hotek JC, et al. Among authors: detwiler tj. J Pharmacol Toxicol Methods. 2023 Nov-Dec;124:107476. doi: 10.1016/j.vascn.2023.107476. Epub 2023 Nov 4. J Pharmacol Toxicol Methods. 2023. PMID: 37931824 Free article.

3

Development and characterization of canine-specific computational models to predict pulsatile arterial hemodynamics and ventricular-arterial coupling.

Hotek JC, Chirinos JA, Detwiler TJ, Regan HK, Regan CP. Hotek JC, et al. Among authors: detwiler tj. Physiol Rep. 2023 Jun;11(11):e15731. doi: 10.14814/phy2.15731. Physiol Rep. 2023. PMID: 37269177 Free PMC article.

4

Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs.

Regan CP, Stump GL, Detwiler TJ, Chen L, Regan HK, Gilberto DB, DeGeorge JJ, Sannajust FJ. Regan CP, et al. Among authors: detwiler tj. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:107-14. doi: 10.1016/j.vascn.2016.05.002. Epub 2016 May 7. J Pharmacol Toxicol Methods. 2016. PMID: 27166580

5

Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.

Lynch JJ Jr, Detwiler TJ, Kane SA, Regan CP. Lynch JJ Jr, et al. Among authors: detwiler tj. J Cardiovasc Pharmacol. 2010 Nov;56(5):518-25. doi: 10.1097/FJC.0b013e3181f5d414. J Cardiovasc Pharmacol. 2010. PMID: 20729756

6

An improved automated method to quantitate infarct volume in triphenyltetrazolium stained rat brain sections.

Regan HK, Detwiler TJ, Huang JC, Lynch JJ, Regan CP. Regan HK, et al. Among authors: detwiler tj. J Pharmacol Toxicol Methods. 2007 Nov-Dec;56(3):339-43. doi: 10.1016/j.vascn.2007.05.005. Epub 2007 Jun 2. J Pharmacol Toxicol Methods. 2007. PMID: 17596972

7

Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists.

Wood MR, Schirripa KM, Kim JJ, Wan BL, Murphy KL, Ransom RW, Chang RS, Tang C, Prueksaritanont T, Detwiler TJ, Hettrick LA, Landis ER, Leonard YM, Krueger JA, Lewis SD, Pettibone DJ, Freidinger RM, Bock MG. Wood MR, et al. Among authors: detwiler tj. J Med Chem. 2006 Feb 23;49(4):1231-4. doi: 10.1021/jm0511280. J Med Chem. 2006. PMID: 16480259

8

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.

Burgey CS, Robinson KA, Lyle TA, Sanderson PE, Lewis SD, Lucas BJ, Krueger JA, Singh R, Miller-Stein C, White RB, Wong B, Lyle EA, Williams PD, Coburn CA, Dorsey BD, Barrow JC, Stranieri MT, Holahan MA, Sitko GR, Cook JJ, McMasters DR, McDonough CM, Sanders WM, Wallace AA, Clayton FC, Bohn D, Leonard YM, Detwiler TJ Jr, Lynch JJ Jr, Yan Y, Chen Z, Kuo L, Gardell SJ, Shafer JA, Vacca JP. Burgey CS, et al. Among authors: detwiler tj jr. J Med Chem. 2003 Feb 13;46(4):461-73. doi: 10.1021/jm020311f. J Med Chem. 2003. PMID: 12570369

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