Mortiboys H - Search Results

1

The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.

McCarron KR, Elcocks H, Mortiboys H, Urbé S, Clague MJ. McCarron KR, et al. Among authors: mortiboys h. Biochem J. 2024 Feb 21;481(4):265-278. doi: 10.1042/BCJ20230492. Biochem J. 2024. PMID: 38299383 Free PMC article.

2

The common PARK8 mutation LRRK2G²⁰¹⁹S is not a risk factor for breast cancer in the absence of Parkinson's disease.

Mortiboys H, Cox A, Brock IW, Bandmann O. Mortiboys H, et al. J Neurol. 2013 Aug;260(8):2177-8. doi: 10.1007/s00415-013-7027-7. Epub 2013 Jul 4. J Neurol. 2013. PMID: 23824357 No abstract available.

3

IHG-1 increases mitochondrial fusion and bioenergetic function.

Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C, Murphy M. Hickey FB, et al. Among authors: mortiboys h. Diabetes. 2014 Dec;63(12):4314-25. doi: 10.2337/db13-1256. Epub 2014 Jul 9. Diabetes. 2014. PMID: 25008184

4

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ. Rusilowicz-Jones EV, et al. Among authors: mortiboys h. Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. Print 2020 Aug. Life Sci Alliance. 2020. PMID: 32636217 Free PMC article.

5

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.

Rusilowicz-Jones EV, Barone FG, Lopes FM, Stephen E, Mortiboys H, Urbé S, Clague MJ. Rusilowicz-Jones EV, et al. Among authors: mortiboys h. Life Sci Alliance. 2021 Nov 29;5(2):e202101287. doi: 10.26508/lsa.202101287. Print 2022 Feb. Life Sci Alliance. 2021. PMID: 34844982 Free PMC article.

6

FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.

Elcocks H, Brazel AJ, McCarron KR, Kaulich M, Husnjak K, Mortiboys H, Clague MJ, Urbé S. Elcocks H, et al. Among authors: mortiboys h. EMBO J. 2023 Jul 3;42(13):e112799. doi: 10.15252/embj.2022112799. Epub 2023 Apr 27. EMBO J. 2023. PMID: 37102372 Free PMC article.

7

Screening for chemical modulators for LRRK2.

Mortiboys H. Mortiboys H. Biochem Soc Trans. 2016 Dec 15;44(6):1617-1623. doi: 10.1042/BST20160242. Biochem Soc Trans. 2016. PMID: 27913670 Free article. Review.

8

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Macdonald R, Barnes K, Hastings C, Mortiboys H. Macdonald R, et al. Among authors: mortiboys h. Biochem Soc Trans. 2018 Aug 20;46(4):891-909. doi: 10.1042/BST20170501. Epub 2018 Jul 19. Biochem Soc Trans. 2018. PMID: 30026371 Free article. Review.

9

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

Mortiboys H, Johansen KK, Aasly JO, Bandmann O. Mortiboys H, et al. Neurology. 2010 Nov 30;75(22):2017-20. doi: 10.1212/WNL.0b013e3181ff9685. Neurology. 2010. PMID: 21115957

10

Direct Reprogramming Retains Aging Signatures That Are Critical to Reveal Parkinson's Disease-Associated Autophagy Phenotypes.

Stephen E, Mortiboys H. Stephen E, et al. Among authors: mortiboys h. Cell Reprogram. 2022 Dec;24(6):327-328. doi: 10.1089/cell.2022.0127. Epub 2022 Nov 17. Cell Reprogram. 2022. PMID: 36394504 No abstract available.

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