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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Schönherr H, Ayaz P, Taylor AM, Casaletto JB, Touré BB, Moustakas DT, Hudson BM, Valverde R, Zhao S, O'Hearn PJ, Foster L, Sharon DA, Garfinkle S, Giordanetto F, Lescarbeau A, Kurukulasuriya R, Gerami-Moayed N, Maglic D, Bruderek K, Naik G, Gunaydin H, Mader MM, Boezio AA, McLean TH, Chen R, Wang Y, Shaw DE, Watters J, Bergstrom DA. Schönherr H, et al. Among authors: foster l. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2317756121. doi: 10.1073/pnas.2317756121. Epub 2024 Feb 1. Proc Natl Acad Sci U S A. 2024. PMID: 38300868 Free PMC article.
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Subbiah V, Sahai V, Maglic D, Bruderek K, Touré BB, Zhao S, Valverde R, O'Hearn PJ, Moustakas DT, Schönherr H, Gerami-Moayed N, Taylor AM, Hudson BM, Houde DJ, Pal D, Foster L, Gunaydin H, Ayaz P, Sharon DA, Goyal L, Schram AM, Kamath S, Sherwin CA, Schmidt-Kittler O, Jen KY, Ricard F, Wolf BB, Shaw DE, Bergstrom DA, Watters J, Casaletto JB. Subbiah V, et al. Among authors: foster l. Cancer Discov. 2023 Sep 6;13(9):2012-2031. doi: 10.1158/2159-8290.CD-23-0475. Cancer Discov. 2023. PMID: 37270847 Free PMC article.
The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.
Thomas JL, McGee KC, Hossain A, Perkins GD, Gordon AC, Young D, McAuley D, Singer M, Lall R, Kramaric T, Lord JM, Whitehouse T, Mur LAJ; STRESS-L. collaborators. Thomas JL, et al. Intensive Care Med Exp. 2025 Jan 22;13(1):9. doi: 10.1186/s40635-024-00708-6. Intensive Care Med Exp. 2025. PMID: 39841388
Single-cell and spatial transcriptomics illuminate bat immunity and barrier tissue evolution.
Levinger R, Tussia-Cohen D, Friedman S, Lender Y, Nissan Y, Fraimovitch E, Gavriel Y, Tearle J, Kolodziejczyk AA, Moon KM, Gomes T, Kunowska N, Weinberg M, Donati G, Foster LJ, James KR, Yovel Y, Hagai T. Levinger R, et al. Among authors: foster lj. Mol Biol Evol. 2025 Jan 21:msaf017. doi: 10.1093/molbev/msaf017. Online ahead of print. Mol Biol Evol. 2025. PMID: 39836373
Regional patterns and climatic predictors of viruses in honey bee (Apis mellifera) colonies over time.
McAfee A, Alavi-Shoushtari N, Labuschagne R, Tran L, Common J, Higo H, Pernal SF, Giovenazzo P, Hoover SE, Guzman-Novoa E, Currie RW, Veiga PW, French SK, Conflitti IM, Pepinelli M, Borges D, Walsh EM, Bishop CA, Zayed A, Duffe J, Guarna MM, Foster LJ. McAfee A, et al. Among authors: foster lj. Sci Rep. 2025 Jan 2;15(1):286. doi: 10.1038/s41598-024-79675-7. Sci Rep. 2025. PMID: 39747229 Free PMC article.
Transfection Potency of Lipid Nanoparticles Containing mRNA Depends on Relative Loading Levels.
Liao S, Wang S, Wadhwa A, Birkenshaw A, Fox K, Cheng MHY, Casmil IC, Magana AA, Bathula NV, Ho CH, Cheng JY, Foster LJ, Harder KW, Ross CJD, Cullis PR, Blakney AK. Liao S, et al. Among authors: foster lj. ACS Appl Mater Interfaces. 2025 Jan 15;17(2):3097-3105. doi: 10.1021/acsami.4c20077. Epub 2024 Dec 31. ACS Appl Mater Interfaces. 2025. PMID: 39737597 Free PMC article.
Bile acid-induced metabolic changes in the colon promote Enterobacteriaceae expansion and associate with dysbiosis in Crohn's disease.
Holani R, Bar-Yoseph H, Krekhno Z, Serapio-Palacios A, Moon KM, Stacey RG, Donald KA, Deng W, Bressler B, Magaña AA, Foster LJ, Atser MG, Johnson JD, Finlay B. Holani R, et al. Among authors: foster lj. Sci Signal. 2024 Dec 17;17(867):eadl1786. doi: 10.1126/scisignal.adl1786. Epub 2024 Dec 17. Sci Signal. 2024. PMID: 39689182
1,093 results