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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.
Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, Gmaschitz G, Phan J, Little A, Abbott JR, Sun Q, Gmachl M, Rudolph D, Arnhof H, Rumpel K, Savarese F, Gerstberger T, Mischerikow N, Treu M, Herdeis L, Wunberg T, Gollner A, Weinstabl H, Mantoulidis A, Krämer O, McConnell DB, W Fesik S. Bröker J, et al. J Med Chem. 2022 Nov 10;65(21):14614-14629. doi: 10.1021/acs.jmedchem.2c01120. Epub 2022 Oct 27. J Med Chem. 2022. PMID: 36300829 Free PMC article.
Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells.
Hieber C, Mustafa AM, Neuroth S, Henninger S, Wollscheid HP, Zabkiewicz J, Lazenby M, Alvares C, Mahboobi S, Butter F, Brenner W, Bros M, Krämer OH. Hieber C, et al. Among authors: kramer oh. Biomed Pharmacother. 2024 Aug;177:117076. doi: 10.1016/j.biopha.2024.117076. Epub 2024 Jul 5. Biomed Pharmacother. 2024. PMID: 38971011 Free article.
Medicinal chemistry advances in targeting class I histone deacetylases.
Abdallah DI, de Araujo ED, Patel NH, Hasan LS, Moriggl R, Krämer OH, Gunning PT. Abdallah DI, et al. Among authors: kramer oh. Explor Target Antitumor Ther. 2023;4(4):757-779. doi: 10.37349/etat.2023.00166. Epub 2023 Aug 31. Explor Target Antitumor Ther. 2023. PMID: 37711592 Free PMC article. Review.
145 results