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The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers.
Perreault M, Means J, Gerson E, James M, Cotton S, Bergeron CG, Simon M, Carlin DA, Schmidt N, Moore TC, Blasbalg J, Sondheimer N, Ndugga-Kabuye K, Denney WS, Isabella VM, Lubkowicz D, Brennan A, Hava DL. Perreault M, et al. Among authors: ndugga kabuye k. Cell Host Microbe. 2024 Mar 13;32(3):382-395.e10. doi: 10.1016/j.chom.2024.01.005. Epub 2024 Feb 2. Cell Host Microbe. 2024. PMID: 38309259 Free article.