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103 results

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Page 1
Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Crespo-Garcia S, et al. Among authors: sapieha p. Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6. Nat Med. 2024. PMID: 38321220 Clinical Trial.
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. Sapieha P, et al. Nat Med. 2008 Oct;14(10):1067-76. doi: 10.1038/nm.1873. Epub 2008 Oct 5. Nat Med. 2008. PMID: 18836459
Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration.
Zhu T, Mancini JA, Sapieha P, Yang C, Joyal JS, Honoré JC, Leduc M, Zaniolo K, Hardy P, Shao Z, Fan L, Hou X, Rivard GE, Chemtob S. Zhu T, et al. Among authors: sapieha p. Am J Physiol Regul Integr Comp Physiol. 2011 Mar;300(3):R577-85. doi: 10.1152/ajpregu.00137.2010. Epub 2010 Dec 15. Am J Physiol Regul Integr Comp Physiol. 2011. PMID: 21160057 Free article.
Choroidal involution is a key component of oxygen-induced retinopathy.
Shao Z, Dorfman AL, Seshadri S, Djavari M, Kermorvant-Duchemin E, Sennlaub F, Blais M, Polosa A, Varma DR, Joyal JS, Lachapelle P, Hardy P, Sitaras N, Picard E, Mancini J, Sapieha P, Chemtob S. Shao Z, et al. Among authors: sapieha p. Invest Ophthalmol Vis Sci. 2011 Aug 5;52(9):6238-48. doi: 10.1167/iovs.10-6742. Invest Ophthalmol Vis Sci. 2011. PMID: 21546530
Understanding retinopathy of prematurity: update on pathogenesis.
Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, Picard E, Zhou E, Lachapelle P, Chemtob S. Rivera JC, et al. Among authors: sapieha p. Neonatology. 2011;100(4):343-53. doi: 10.1159/000330174. Epub 2011 Oct 3. Neonatology. 2011. PMID: 21968165 Review.
Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.
Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P. Binet F, et al. Among authors: sapieha p. Cell Metab. 2013 Mar 5;17(3):353-71. doi: 10.1016/j.cmet.2013.02.003. Cell Metab. 2013. PMID: 23473031 Free article.
Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions.
Favret S, Binet F, Lapalme E, Leboeuf D, Carbadillo J, Rubic T, Picard E, Mawambo G, Tetreault N, Joyal JS, Chemtob S, Sennlaub F, Sangiovanni JP, Guimond M, Sapieha P. Favret S, et al. Among authors: sapieha p. Aging (Albany NY). 2013 Jun;5(6):427-44. doi: 10.18632/aging.100563. Aging (Albany NY). 2013. PMID: 23833031 Free PMC article.
103 results