Yan NL - Search Results

1

The conformational landscape of human transthyretin revealed by cryo-EM.

Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC. Basanta B, et al. Among authors: yan nl. bioRxiv [Preprint]. 2024 Jan 23:2024.01.23.576879. doi: 10.1101/2024.01.23.576879. bioRxiv. 2024. PMID: 38328110 Free PMC article. Preprint.

2

Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy.

Yan NL, Candido F, Tse E, Melo AA, Prusiner SB, Mordes DA, Southworth DR, Paras NA, Merz GE. Yan NL, et al. FEBS Lett. 2025 Jan;599(1):33-40. doi: 10.1002/1873-3468.15048. Epub 2024 Nov 7. FEBS Lett. 2025. PMID: 39511911 Free PMC article.

3

The conformational landscape of human transthyretin revealed by cryo-EM.

Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC. Basanta B, et al. Among authors: yan nl. Nat Struct Mol Biol. 2025 Jan 22. doi: 10.1038/s41594-024-01472-7. Online ahead of print. Nat Struct Mol Biol. 2025. PMID: 39843982

4

Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.

Lederberg OL, Yan NL, Sanchez J, Ren W, Ash C, Wilkens SJ, Qiu H, Qin B, Grant VH, Jackman AB, Stanfield RL, Wilson IA, Petrassi HM, Rhoades D, Kelly JW. Lederberg OL, et al. Among authors: yan nl. J Med Chem. 2024 Dec 12;67(23):21070-21105. doi: 10.1021/acs.jmedchem.4c01773. Epub 2024 Dec 3. J Med Chem. 2024. PMID: 39626211

5

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.

Yan NL, Morgan GJ, Petrassi HM, Wilson IA, Kelly JW. Yan NL, et al. Curr Opin Chem Biol. 2023 Aug;75:102319. doi: 10.1016/j.cbpa.2023.102319. Epub 2023 Jun 6. Curr Opin Chem Biol. 2023. PMID: 37279624 Free PMC article. Review.

6

Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.

Yan NL, Nair R, Chu A, Wilson IA, Johnson KA, Morgan GJ, Kelly JW. Yan NL, et al. Bioorg Med Chem Lett. 2022 Mar 15;60:128571. doi: 10.1016/j.bmcl.2022.128571. Epub 2022 Jan 19. Bioorg Med Chem Lett. 2022. PMID: 35065233 Free PMC article.

7

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

Yan NL, Santos-Martins D, Nair R, Chu A, Wilson IA, Johnson KA, Forli S, Morgan GJ, Petrassi HM, Kelly JW. Yan NL, et al. J Med Chem. 2021 May 13;64(9):6273-6299. doi: 10.1021/acs.jmedchem.1c00339. Epub 2021 May 3. J Med Chem. 2021. PMID: 33939422 Free PMC article.

8

Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.

Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Yan NL, et al. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127356. doi: 10.1016/j.bmcl.2020.127356. Epub 2020 Jun 16. Bioorg Med Chem Lett. 2020. PMID: 32631553 Free PMC article.

9

Stabilization of amyloidogenic immunoglobulin light chains by small molecules.

Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW. Morgan GJ, et al. Among authors: yan nl. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8360-8369. doi: 10.1073/pnas.1817567116. Epub 2019 Apr 10. Proc Natl Acad Sci U S A. 2019. PMID: 30971495 Free PMC article.

10

Post-Translational Backbone Engineering through Selenomethionine-Mediated Incorporation of Freidinger Lactams.

Flood DT, Yan NL, Dawson PE. Flood DT, et al. Among authors: yan nl. Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8697-8701. doi: 10.1002/anie.201804885. Epub 2018 Jun 11. Angew Chem Int Ed Engl. 2018. PMID: 29797386 Free PMC article.

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