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Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity.
Bennett CL, Dastidar S, Arnold FJ, McKinstry SU, Stockford C, Freibaum BD, Sopher BL, Wu M, Seidner G, Joiner W, Taylor JP, West RJH, La Spada AR. Bennett CL, et al. Among authors: stockford c. Acta Neuropathol Commun. 2023 Oct 17;11(1):164. doi: 10.1186/s40478-023-01665-z. Acta Neuropathol Commun. 2023. PMID: 37845749 Free PMC article.