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Lineage-specific intolerance to oncogenic drivers restricts histological transformation.
Science. 2024 Feb 9;383(6683):eadj1415. doi: 10.1126/science.adj1415. Epub 2024 Feb 9.
Science. 2024.
PMID: 38330136
Free PMC article.
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation.
Rogava M, Aprati TJ, Chi WY, Melms JC, Hug C, Davis SH, Earlie EM, Chung C, Deshmukh SK, Wu S, Sledge G, Tang S, Ho P, Amin AD, Caprio L, Gurjao C, Tagore S, Ngo B, Lee MJ, Zanetti G, Wang Y, Chen S, Ge W, Melo LMN, Allies G, Rösler J, Gibney GT, Schmitz OJ, Sykes M, Creusot RJ, Tüting T, Schadendorf D, Röcken M, Eigentler TK, Molotkov A, Mintz A, Bakhoum SF, Beyaz S, Cantley LC, Sorger PK, Meckelmann SW, Tasdogan A, Liu D, Laughney AM, Izar B.
Rogava M, et al. Among authors: earlie em.
Nat Cancer. 2024 Mar;5(3):433-447. doi: 10.1038/s43018-023-00704-x. Epub 2024 Jan 29.
Nat Cancer. 2024.
PMID: 38286827
Free PMC article.
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Non-cell-autonomous cancer progression from chromosomal instability.
Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF.
Li J, et al. Among authors: earlie em.
Nature. 2023 Aug;620(7976):1080-1088. doi: 10.1038/s41586-023-06464-z. Epub 2023 Aug 23.
Nature. 2023.
PMID: 37612508
Free PMC article.
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Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.
Bakhoum MF, Francis JH, Agustinus A, Earlie EM, Di Bona M, Abramson DH, Duran M, Masilionis I, Molina E, Shoushtari AN, Goldbaum MH, Mischel PS, Bakhoum SF, Laughney AM.
Bakhoum MF, et al. Among authors: earlie em.
Nat Commun. 2021 Sep 13;12(1):5402. doi: 10.1038/s41467-021-25529-z.
Nat Commun. 2021.
PMID: 34518527
Free PMC article.
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