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Page 1
Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
Gimenez LE, Martin C, Yu J, Hollanders C, Hernandez CC, Wu Y, Yao D, Han GW, Dahir NS, Wu L, Van der Poorten O, Lamouroux A, Mannes M, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. Gimenez LE, et al. Among authors: han gw. J Med Chem. 2024 Feb 22;67(4):2690-2711. doi: 10.1021/acs.jmedchem.3c01822. Epub 2024 Feb 12. J Med Chem. 2024. PMID: 38345933
The activation mechanism and antibody binding mode for orphan GPR20.
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F. Lin X, et al. Among authors: han gw. Cell Discov. 2023 Feb 28;9(1):23. doi: 10.1038/s41421-023-00520-8. Cell Discov. 2023. PMID: 36849514 Free PMC article.
Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes.
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C. Tyson AS, et al. Among authors: han gw. Nat Chem Biol. 2025 Jan 7. doi: 10.1038/s41589-024-01812-0. Online ahead of print. Nat Chem Biol. 2025. PMID: 39775170
An opioid efficacy switch for reversible optical control of peripheral analgesia.
Posa L, Romano G, Ji X, Khan S, Paz BM, Han GW, Nazarova AL, Zaidi SA, Ranjbar M, Pleil K, Katritch V, Gati C, Trauner D, Levitz J. Posa L, et al. Among authors: han gw. bioRxiv [Preprint]. 2025 Jan 5:2024.12.16.628735. doi: 10.1101/2024.12.16.628735. bioRxiv. 2025. PMID: 39764058 Free PMC article. Preprint.
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V. Barekatain M, et al. Among authors: han gw. Sci Signal. 2024 Dec 3;17(865):eado8741. doi: 10.1126/scisignal.ado8741. Epub 2024 Dec 3. Sci Signal. 2024. PMID: 39626010
Structural insights into the human niacin receptor HCA2-Gi signalling complex.
Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ. Yang Y, et al. Among authors: han gw. Nat Commun. 2023 Mar 27;14(1):1692. doi: 10.1038/s41467-023-37177-6. Nat Commun. 2023. PMID: 36973264 Free PMC article.
194 results