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Page 1
Single-molecule chromatin configurations link transcription factor binding to expression in human cells.
Doughty BR, Hinks MM, Schaepe JM, Marinov GK, Thurm AR, Rios-Martinez C, Parks BE, Tan Y, Marklund E, Dubocanin D, Bintu L, Greenleaf WJ. Doughty BR, et al. bioRxiv [Preprint]. 2024 Feb 4:2024.02.02.578660. doi: 10.1101/2024.02.02.578660. bioRxiv. 2024. Update in: Nature. 2024 Dec;636(8043):745-754. doi: 10.1038/s41586-024-08219-w PMID: 38352517 Free PMC article. Updated. Preprint.
Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.
Fulco CP, Nasser J, Jones TR, Munson G, Bergman DT, Subramanian V, Grossman SR, Anyoha R, Doughty BR, Patwardhan TA, Nguyen TH, Kane M, Perez EM, Durand NC, Lareau CA, Stamenova EK, Aiden EL, Lander ES, Engreitz JM. Fulco CP, et al. Among authors: doughty br. Nat Genet. 2019 Dec;51(12):1664-1669. doi: 10.1038/s41588-019-0538-0. Epub 2019 Nov 29. Nat Genet. 2019. PMID: 31784727 Free PMC article.
HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes.
Marshall JL, Doughty BR, Subramanian V, Guckelberger P, Wang Q, Chen LM, Rodriques SG, Zhang K, Fulco CP, Nasser J, Grinkevich EJ, Noel T, Mangiameli S, Bergman DT, Greka A, Lander ES, Chen F, Engreitz JM. Marshall JL, et al. Among authors: doughty br. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33404-33413. doi: 10.1073/pnas.2010738117. Epub 2020 Dec 21. Proc Natl Acad Sci U S A. 2020. PMID: 33376219 Free PMC article.
Single-cell chromatin state transitions during epigenetic memory formation.
Fujimori T, Rios-Martinez C, Thurm AR, Hinks MM, Doughty BR, Sinha J, Le D, Hafner A, Greenleaf WJ, Boettiger AN, Bintu L. Fujimori T, et al. Among authors: doughty br. bioRxiv [Preprint]. 2023 Oct 5:2023.10.03.560616. doi: 10.1101/2023.10.03.560616. bioRxiv. 2023. PMID: 37873344 Free PMC article. Preprint.
An encyclopedia of enhancer-gene regulatory interactions in the human genome.
Gschwind AR, Mualim KS, Karbalayghareh A, Sheth MU, Dey KK, Jagoda E, Nurtdinov RN, Xi W, Tan AS, Jones H, Ma XR, Yao D, Nasser J, Avsec Ž, James BT, Shamim MS, Durand NC, Rao SSP, Mahajan R, Doughty BR, Andreeva K, Ulirsch JC, Fan K, Perez EM, Nguyen TC, Kelley DR, Finucane HK, Moore JE, Weng Z, Kellis M, Bassik MC, Price AL, Beer MA, Guigó R, Stamatoyannopoulos JA, Lieberman Aiden E, Greenleaf WJ, Leslie CS, Steinmetz LM, Kundaje A, Engreitz JM. Gschwind AR, et al. Among authors: doughty br. bioRxiv [Preprint]. 2023 Nov 13:2023.11.09.563812. doi: 10.1101/2023.11.09.563812. bioRxiv. 2023. PMID: 38014075 Free PMC article. Preprint.
Multicenter integrated analysis of noncoding CRISPRi screens.
Yao D, Tycko J, Oh JW, Bounds LR, Gosai SJ, Lataniotis L, Mackay-Smith A, Doughty BR, Gabdank I, Schmidt H, Guerrero-Altamirano T, Siklenka K, Guo K, White AD, Youngworth I, Andreeva K, Ren X, Barrera A, Luo Y, Yardımcı GG, Tewhey R, Kundaje A, Greenleaf WJ, Sabeti PC, Leslie C, Pritykin Y, Moore JE, Beer MA, Gersbach CA, Reddy TE, Shen Y, Engreitz JM, Bassik MC, Reilly SK. Yao D, et al. Among authors: doughty br. Nat Methods. 2024 Apr;21(4):723-734. doi: 10.1038/s41592-024-02216-7. Epub 2024 Mar 19. Nat Methods. 2024. PMID: 38504114 Free PMC article.
Cohesin-mediated 3D contacts tune enhancer-promoter regulation.
Guckelberger P, Doughty BR, Munson G, Rao SSP, Tan Y, Cai XS, Fulco CP, Nasser J, Mualim KS, Bergman DT, Ray J, Jagoda E, Munger CJ, Gschwind AR, Sheth MU, Tan AS, Pulido SG, Mitra N, Weisz D, Shamim MS, Durand NC, Mahajan R, Khan R, Steinmetz LM, Kanemaki MT, Lander ES, Meissner A, Aiden EL, Engreitz JM. Guckelberger P, et al. Among authors: doughty br. bioRxiv [Preprint]. 2024 Jul 22:2024.07.12.603288. doi: 10.1101/2024.07.12.603288. bioRxiv. 2024. PMID: 39026740 Free PMC article. Preprint.
Single-molecule states link transcription factor binding to gene expression.
Doughty BR, Hinks MM, Schaepe JM, Marinov GK, Thurm AR, Rios-Martinez C, Parks BE, Tan Y, Marklund E, Dubocanin D, Bintu L, Greenleaf WJ. Doughty BR, et al. Nature. 2024 Dec;636(8043):745-754. doi: 10.1038/s41586-024-08219-w. Epub 2024 Nov 20. Nature. 2024. PMID: 39567683
16 results