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13,009 results

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
Liang WC, Xi H, Sun D, D'Ascenzo L, Zarzar J, Stephens N, Cook R, Li Y, Ye Z, Matsumoto M, Payandeh J, Masureel M, Wu Y. Liang WC, et al. Among authors: sun d, d ascenzo l. MAbs. 2024 Jan-Dec;16(1):2309685. doi: 10.1080/19420862.2024.2309685. Epub 2024 Feb 14. MAbs. 2024. PMID: 38356181 Free PMC article.
Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal.
Storek KM, Auerbach MR, Shi H, Garcia NK, Sun D, Nickerson NN, Vij R, Lin Z, Chiang N, Schneider K, Wecksler AT, Skippington E, Nakamura G, Seshasayee D, Koerber JT, Payandeh J, Smith PA, Rutherford ST. Storek KM, et al. Among authors: sun d. Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3692-3697. doi: 10.1073/pnas.1800043115. Epub 2018 Mar 19. Proc Natl Acad Sci U S A. 2018. PMID: 29555747 Free PMC article.
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M. Sun D, et al. Among authors: sun y. Nat Commun. 2023 Dec 1;14(1):7940. doi: 10.1038/s41467-023-43601-8. Nat Commun. 2023. PMID: 38040762 Free PMC article.
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
Dorel R, Sun D, Carruthers N, Castanedo GM, Ung PM, Factor DC, Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ, Harper HE, Stubblefield S, Payandeh J, McHugh D, Lang BT, Tesar PJ, Dere E, Masureel M, Adams DJ, Volgraf M, Braun MG. Dorel R, et al. Among authors: sun d. J Med Chem. 2024 Mar 28;67(6):4819-4832. doi: 10.1021/acs.jmedchem.3c02396. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38470227
The discovery and structural basis of two distinct state-dependent inhibitors of BamA.
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J. Sun D, et al. Nat Commun. 2024 Oct 8;15(1):8718. doi: 10.1038/s41467-024-52512-1. Nat Commun. 2024. PMID: 39379361 Free PMC article.
Inhibitors targeting BamA in gram-negative bacteria.
Storek KM, Sun D, Rutherford ST. Storek KM, et al. Among authors: sun d. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119609. doi: 10.1016/j.bbamcr.2023.119609. Epub 2023 Oct 16. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 37852326 Free article. Review.
Peptidoglycan maturation controls outer membrane protein assembly.
Mamou G, Corona F, Cohen-Khait R, Housden NG, Yeung V, Sun D, Sridhar P, Pazos M, Knowles TJ, Kleanthous C, Vollmer W. Mamou G, et al. Among authors: sun d. Nature. 2022 Jun;606(7916):953-959. doi: 10.1038/s41586-022-04834-7. Epub 2022 Jun 15. Nature. 2022. PMID: 35705811 Free PMC article.
Lipids mediate supramolecular outer membrane protein assembly in bacteria.
Webby MN, Oluwole AO, Pedebos C, Inns PG, Olerinyova A, Prakaash D, Housden NG, Benn G, Sun D, Hoogenboom BW, Kukura P, Mohammed S, Robinson CV, Khalid S, Kleanthous C. Webby MN, et al. Among authors: sun d. Sci Adv. 2022 Nov 4;8(44):eadc9566. doi: 10.1126/sciadv.adc9566. Epub 2022 Nov 2. Sci Adv. 2022. PMID: 36322653 Free PMC article.
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