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Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Liu S, Desharnais J, Sahasrabudhe PV, Jin P, Li W, Oates BD, Shanker S, Banker ME, Chrunyk BA, Song X, Feng X, Griffor M, Jimenez J, Chen G, Tumelty D, Bhat A, Bradshaw CW, Woodnutt G, Lappe RW, Thorarensen A, Qiu X, Withka JM, Wood LD. Liu S, et al. Among authors: woodnutt g. Sci Rep. 2016 May 17;6:26071. doi: 10.1038/srep26071. Sci Rep. 2016. PMID: 27184415 Free PMC article.
Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody.
Huang J, Ishino T, Chen G, Rolzin P, Osothprarop TF, Retting K, Li L, Jin P, Matin MJ, Huyghe B, Talukdar S, Bradshaw CW, Palanki M, Violand BN, Woodnutt G, Lappe RW, Ogilvie K, Levin N. Huang J, et al. Among authors: woodnutt g. J Pharmacol Exp Ther. 2013 Aug;346(2):270-80. doi: 10.1124/jpet.113.204420. Epub 2013 May 29. J Pharmacol Exp Ther. 2013. PMID: 23720456
Antitumor efficacy of a thrombospondin 1 mimetic CovX-body.
Li L, Leedom TA, Do J, Huang H, Lai J, Johnson K, Osothprarop TF, Rizzo JD, Doppalapudi VR, Bradshaw CW, Lappe RW, Woodnutt G, Levin NJ, Pirie-Shepherd SR. Li L, et al. Among authors: woodnutt g. Transl Oncol. 2011 Aug;4(4):249-57. doi: 10.1593/tlo.11136. Epub 2011 Aug 1. Transl Oncol. 2011. PMID: 21804921 Free PMC article.
Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.
Bower KE, Lam SN, Oates BD, Del Rosario JR, Corner E, Osothprarop TF, Kinhikar AG, Hoye JA, Preston RR, Murphy RE, Campbell LA, Huang H, Jimenez J, Cao X, Chen G, Ainekulu ZW, Datt AB, Levin NJ, Doppalapudi VR, Pirie-Shepherd SR, Bradshaw C, Woodnutt G, Lappe RW. Bower KE, et al. Among authors: woodnutt g. J Med Chem. 2011 Mar 10;54(5):1256-65. doi: 10.1021/jm101226k. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280651
Chemical generation of bispecific antibodies.
Doppalapudi VR, Huang J, Liu D, Jin P, Liu B, Li L, Desharnais J, Hagen C, Levin NJ, Shields MJ, Parish M, Murphy RE, Del Rosario J, Oates BD, Lai JY, Matin MJ, Ainekulu Z, Bhat A, Bradshaw CW, Woodnutt G, Lerner RA, Lappe RW. Doppalapudi VR, et al. Among authors: woodnutt g. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22611-6. doi: 10.1073/pnas.1016478108. Epub 2010 Dec 13. Proc Natl Acad Sci U S A. 2010. PMID: 21149738 Free PMC article.
Targeting the ANGPT-TIE2 pathway in malignancy.
Huang H, Bhat A, Woodnutt G, Lappe R. Huang H, et al. Among authors: woodnutt g. Nat Rev Cancer. 2010 Aug;10(8):575-85. doi: 10.1038/nrc2894. Nat Rev Cancer. 2010. PMID: 20651738 Review.
49 results