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Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity.
Baumgartner F, Bamopoulos SA, Faletti L, Hsiao HJ, Holz M, Gonzalez-Menendez I, Solé-Boldo L, Horne A, Gosavi S, Özerdem C, Singh N, Liebig S, Ramamoorthy S, Lehmann M, Demel U, Kühl AA, Wartewig T, Ruland J, Wunderlich FT, Schick M, Walther W, Rose-John S, Haas S, Quintanilla-Martinez L, Feske S, Ehl S, Glauben R, Keller U. Baumgartner F, et al. Among authors: keller u. Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20. Sci Signal. 2024. PMID: 38377177
GP130 activation induces myeloma and collaborates with MYC.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U. Dechow T, et al. Among authors: keller u. J Clin Invest. 2014 Dec;124(12):5263-74. doi: 10.1172/JCI69094. Epub 2014 Nov 10. J Clin Invest. 2014. PMID: 25384216 Free PMC article. Clinical Trial.
PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.
Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Öllinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwälder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadiñanos J, Bradley A, Rad R. Weber J, et al. Among authors: keller u. Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3. Nat Commun. 2019. PMID: 30926791 Free PMC article.
Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.
Scherger AK, Al-Maarri M, Maurer HC, Schick M, Maurer S, Öllinger R, Gonzalez-Menendez I, Martella M, Thaler M, Pechloff K, Steiger K, Sander S, Ruland J, Rad R, Quintanilla-Martinez L, Wunderlich FT, Rose-John S, Keller U. Scherger AK, et al. Among authors: keller u. JCI Insight. 2019 Aug 8;4(15):e128435. doi: 10.1172/jci.insight.128435. eCollection 2019 Aug 8. JCI Insight. 2019. PMID: 31391340 Free PMC article.
The SUMO pathway in pancreatic cancer: insights and inhibition.
Schneeweis C, Hassan Z, Schick M, Keller U, Schneider G. Schneeweis C, et al. Among authors: keller u. Br J Cancer. 2021 Feb;124(3):531-538. doi: 10.1038/s41416-020-01119-6. Epub 2020 Oct 19. Br J Cancer. 2021. PMID: 33071285 Free PMC article. Review.
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel UM, Böger M, Yousefian S, Grunert C, Zhang L, Hotz PW, Gottschlich A, Köse H, Isaakidis K, Vonficht D, Grünschläger F, Rohleder E, Wagner K, Dönig J, Igl V, Brzezicha B, Baumgartner F, Habringer S, Löber J, Chapuy B, Weidinger C, Kobold S, Haas S, Busse AB, Müller S, Wirth M, Schick M, Keller U. Demel UM, et al. Among authors: keller u. J Clin Invest. 2022 May 2;132(9):e152383. doi: 10.1172/JCI152383. J Clin Invest. 2022. PMID: 35499080 Free PMC article.
Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy.
Demel UM, Wirth M, Yousefian S, Zhang L, Isaakidis K, Dönig J, Böger M, Singh N, Köse H, Haas S, Müller S, Schick M, Keller U. Demel UM, et al. Among authors: keller u. Haematologica. 2023 Feb 1;108(2):555-567. doi: 10.3324/haematol.2022.280995. Haematologica. 2023. PMID: 36134453 Free PMC article.
960 results