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224 results

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Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity.
Baumgartner F, Bamopoulos SA, Faletti L, Hsiao HJ, Holz M, Gonzalez-Menendez I, Solé-Boldo L, Horne A, Gosavi S, Özerdem C, Singh N, Liebig S, Ramamoorthy S, Lehmann M, Demel U, Kühl AA, Wartewig T, Ruland J, Wunderlich FT, Schick M, Walther W, Rose-John S, Haas S, Quintanilla-Martinez L, Feske S, Ehl S, Glauben R, Keller U. Baumgartner F, et al. Among authors: ruland j. Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20. Sci Signal. 2024. PMID: 38377177
GP130 activation induces myeloma and collaborates with MYC.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U. Dechow T, et al. Among authors: ruland j. J Clin Invest. 2014 Dec;124(12):5263-74. doi: 10.1172/JCI69094. Epub 2014 Nov 10. J Clin Invest. 2014. PMID: 25384216 Free PMC article. Clinical Trial.
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Öllinger R, Maresch R, Buch T, Steiger K, Winter C, Rad R, Ruland J. Wartewig T, et al. Among authors: ruland j. Nature. 2017 Dec 7;552(7683):121-125. doi: 10.1038/nature24649. Epub 2017 Nov 15. Nature. 2017. PMID: 29143824 Free PMC article.
PD-1 Tumor Suppressor Signaling in T Cell Lymphomas.
Wartewig T, Ruland J. Wartewig T, et al. Among authors: ruland j. Trends Immunol. 2019 May;40(5):403-414. doi: 10.1016/j.it.2019.03.005. Epub 2019 Apr 9. Trends Immunol. 2019. PMID: 30979616 Review.
Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.
Scherger AK, Al-Maarri M, Maurer HC, Schick M, Maurer S, Öllinger R, Gonzalez-Menendez I, Martella M, Thaler M, Pechloff K, Steiger K, Sander S, Ruland J, Rad R, Quintanilla-Martinez L, Wunderlich FT, Rose-John S, Keller U. Scherger AK, et al. Among authors: ruland j. JCI Insight. 2019 Aug 8;4(15):e128435. doi: 10.1172/jci.insight.128435. eCollection 2019 Aug 8. JCI Insight. 2019. PMID: 31391340 Free PMC article.
The uric acid crystal receptor Clec12A potentiates type I interferon responses.
Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J. Li K, et al. Among authors: ruland j. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549. doi: 10.1073/pnas.1821351116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451663 Free PMC article.
224 results