Elledge SJ - Search Results

1

Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns.

Watson EV, Lee JJ, Gulhan DC, Melloni GEM, Venev SV, Magesh RY, Frederick A, Chiba K, Wooten EC, Naxerova K, Dekker J, Park PJ, Elledge SJ. Watson EV, et al. Among authors: elledge sj. Nat Genet. 2024 May;56(5):900-912. doi: 10.1038/s41588-024-01665-2. Epub 2024 Feb 22. Nat Genet. 2024. PMID: 38388848 Free PMC article.

2

Systematic identification of synergistic drug pairs targeting HIV.

Tan X, Hu L, Luquette LJ 3rd, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ. Tan X, et al. Among authors: elledge sj. Nat Biotechnol. 2012 Nov;30(11):1125-30. doi: 10.1038/nbt.2391. Epub 2012 Oct 14. Nat Biotechnol. 2012. PMID: 23064238 Free PMC article.

3

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.

Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Davoli T, et al. Among authors: elledge sj. Cell. 2013 Nov 7;155(4):948-62. doi: 10.1016/j.cell.2013.10.011. Epub 2013 Oct 31. Cell. 2013. PMID: 24183448 Free PMC article.

4

Taking the brakes off telomerase.

Naxerova K, Elledge SJ. Naxerova K, et al. Among authors: elledge sj. Elife. 2015 Jul 21;4:e09519. doi: 10.7554/eLife.09519. Elife. 2015. PMID: 26194808 Free PMC article.

5

Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.

Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Davoli T, et al. Among authors: elledge sj. Genes Dev. 2016 Dec 15;30(24):2684-2695. doi: 10.1101/gad.290122.116. Genes Dev. 2016. PMID: 28087713 Free PMC article.

6

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.

Davoli T, Uno H, Wooten EC, Elledge SJ. Davoli T, et al. Among authors: elledge sj. Science. 2017 Jan 20;355(6322):eaaf8399. doi: 10.1126/science.aaf8399. Science. 2017. PMID: 28104840 Free PMC article.

7

Origins of lymphatic and distant metastases in human colorectal cancer.

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Naxerova K, et al. Among authors: elledge sj. Science. 2017 Jul 7;357(6346):55-60. doi: 10.1126/science.aai8515. Science. 2017. PMID: 28684519 Free PMC article.

8

Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown!

Watson EV, Elledge SJ. Watson EV, et al. Among authors: elledge sj. Trends Genet. 2017 Oct;33(10):662-664. doi: 10.1016/j.tig.2017.07.007. Epub 2017 Aug 8. Trends Genet. 2017. PMID: 28800914

9

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Sack LM, et al. Among authors: elledge sj. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. Cell. 2018. PMID: 29576454 Free PMC article.

10

Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.

Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ. Naxerova K, et al. Among authors: elledge sj. Genes Dev. 2021 Nov 1;35(21-22):1527-1547. doi: 10.1101/gad.349048.121. Epub 2021 Oct 28. Genes Dev. 2021. PMID: 34711655 Free PMC article.

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