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Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects.
Miller LR, Bickel MA, Vance ML, Vaden H, Nagykaldi D, Nyul-Toth A, Bullen EC, Gautam T, Tarantini S, Yabluchanskiy A, Kiss T, Ungvari Z, Conley SM. Miller LR, et al. Among authors: gautam t. Geroscience. 2024 Jun;46(3):3481-3501. doi: 10.1007/s11357-024-01090-7. Epub 2024 Feb 23. Geroscience. 2024. PMID: 38388918 Free PMC article.
Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Csipo T, Nyúl-Tóth Á, Lipecz A, Szabo C, Farkas E, Wren JD, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: gautam t. Geroscience. 2019 Aug;41(4):419-439. doi: 10.1007/s11357-019-00095-x. Epub 2019 Aug 28. Geroscience. 2019. PMID: 31463647 Free PMC article.
Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole N, Gautam T, Giles CB, Wren JD, Sonntag WE, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: gautam t. Aging Cell. 2017 Jun;16(3):469-479. doi: 10.1111/acel.12583. Epub 2017 Mar 14. Aging Cell. 2017. PMID: 28295976 Free PMC article.
Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment.
Tucsek Z, Noa Valcarcel-Ares M, Tarantini S, Yabluchanskiy A, Fülöp G, Gautam T, Orock A, Csiszar A, Deak F, Ungvari Z. Tucsek Z, et al. Among authors: gautam t. Geroscience. 2017 Aug;39(4):385-406. doi: 10.1007/s11357-017-9981-y. Epub 2017 Jun 29. Geroscience. 2017. PMID: 28664509 Free PMC article.
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Tarantini S, et al. Among authors: gautam t. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177. J Gerontol A Biol Sci Med Sci. 2018. PMID: 29905772 Free PMC article.
IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
Toth P, Tucsek Z, Tarantini S, Sosnowska D, Gautam T, Mitschelen M, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Toth P, et al. Among authors: gautam t. J Cereb Blood Flow Metab. 2014 Dec;34(12):1887-97. doi: 10.1038/jcbfm.2014.156. Epub 2014 Sep 24. J Cereb Blood Flow Metab. 2014. PMID: 25248835 Free PMC article.
Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. Tarantini S, et al. Among authors: gautam t. Age (Dordr). 2016 Aug;38(4):273-289. doi: 10.1007/s11357-016-9931-0. Epub 2016 Sep 9. Age (Dordr). 2016. PMID: 27613724 Free PMC article.
The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
Podlutsky A, Valcarcel-Ares MN, Yancey K, Podlutskaya V, Nagykaldi E, Gautam T, Miller RA, Sonntag WE, Csiszar A, Ungvari Z. Podlutsky A, et al. Among authors: gautam t. Geroscience. 2017 Apr;39(2):147-160. doi: 10.1007/s11357-017-9966-x. Epub 2017 Feb 23. Geroscience. 2017. PMID: 28233247 Free PMC article.
Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Fulop GA, Hertelendy P, Gautam T, Farkas E, Perz A, Rabinovitch PS, Sonntag WE, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: gautam t. Aging Cell. 2018 Apr;17(2):e12731. doi: 10.1111/acel.12731. Epub 2018 Feb 6. Aging Cell. 2018. PMID: 29405550 Free PMC article.
85 results