Selkoe DJ - Search Results

1

Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.

Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Nuber S, et al. Among authors: selkoe dj. NPJ Parkinsons Dis. 2024 Feb 29;10(1):47. doi: 10.1038/s41531-024-00662-w. NPJ Parkinsons Dis. 2024. PMID: 38424059 Free PMC article.

2

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. Dettmer U, et al. J Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319586 Free PMC article.

3

Defining the native state of α-synuclein.

Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Selkoe D, et al. Neurodegener Dis. 2014;13(2-3):114-7. doi: 10.1159/000355516. Epub 2013 Oct 30. Neurodegener Dis. 2014. PMID: 24192542 Review.

4

A new method for quantitative immunoblotting of endogenous α-synuclein.

Newman AJ, Selkoe D, Dettmer U. Newman AJ, et al. PLoS One. 2013 Nov 20;8(11):e81314. doi: 10.1371/journal.pone.0081314. eCollection 2013. PLoS One. 2013. PMID: 24278419 Free PMC article.

5

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Luth ES, et al. Among authors: selkoe dj. Biochemistry. 2015 Jan 20;54(2):279-92. doi: 10.1021/bi501188a. Epub 2014 Dec 23. Biochemistry. 2015. PMID: 25490121 Free PMC article.

6

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. Nat Commun. 2015. PMID: 26076669 Free PMC article.

7

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. Dettmer U, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9596-601. doi: 10.1073/pnas.1505953112. Epub 2015 Jul 7. Proc Natl Acad Sci U S A. 2015. PMID: 26153422 Free PMC article.

8

New insights into cellular α-synuclein homeostasis in health and disease.

Dettmer U, Selkoe D, Bartels T. Dettmer U, et al. Curr Opin Neurobiol. 2016 Feb;36:15-22. doi: 10.1016/j.conb.2015.07.007. Epub 2015 Aug 15. Curr Opin Neurobiol. 2016. PMID: 26282834 Review.

9

Caspase-1 clipping causes complications for α-synuclein.

Nuber S, Selkoe DJ. Nuber S, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9958-60. doi: 10.1073/pnas.1610993113. Epub 2016 Aug 22. Proc Natl Acad Sci U S A. 2016. PMID: 27551083 Free PMC article. No abstract available.

10

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Dettmer U, et al. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. Hum Mol Genet. 2017. PMID: 28911198 Free PMC article.

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