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Page 1
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies.
Fer M, Amalric C, Arban R, Baron L, Ben Hamida S, Breh-Schlanser P, Cui Y, Darcq E, Eickmeier C, Faye V, Franchet C, Frauli M, Halter C, Heyer M, Hoenke C, Hoerer S, Hucke OT, Joseph C, Kieffer BL, Lebrun L, Lotz N, Mayer S, Omrani A, Recolet M, Schaeffer L, Schann S, Schlecker A, Steinberg E, Viloria M, Würstle K, Young K, Zinser A, Montel F, Klepp J. Fer M, et al. Among authors: schann s. J Med Chem. 2024 Jul 11;67(13):11296-11325. doi: 10.1021/acs.jmedchem.4c00665. Epub 2024 Jul 1. J Med Chem. 2024. PMID: 38949964
Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo.
Schiemann K, Belousova N, Matevossian A, Nallaparaju KC, Kradjian G, Pandya M, Chen Z, Aral E, Krauel EM, Petrova E, Boesler C, Kitzing T, Lecomte M, Wagner C, Blayo AL, Schann S, Huck B, Moisan J, Zaynagetdinov R. Schiemann K, et al. Among authors: schann s. Mol Cancer Ther. 2024 Nov 4;23(11):1517-1529. doi: 10.1158/1535-7163.MCT-23-0843. Mol Cancer Ther. 2024. PMID: 39162025
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V, St-Onge S, Carrier M, Héroux M, Morissette S, Fauman EB, Fortin JP, Schann S, Leroy X, Gloriam DE, Bouvier M. Avet C, et al. Among authors: schann s. Elife. 2022 Mar 18;11:e74101. doi: 10.7554/eLife.74101. Elife. 2022. PMID: 35302493 Free PMC article.
Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.
Charvin D, Pomel V, Ortiz M, Frauli M, Scheffler S, Steinberg E, Baron L, Deshons L, Rudigier R, Thiarc D, Morice C, Manteau B, Mayer S, Graham D, Giethlen B, Brugger N, Hédou G, Conquet F, Schann S. Charvin D, et al. Among authors: schann s. J Med Chem. 2017 Oct 26;60(20):8515-8537. doi: 10.1021/acs.jmedchem.7b00991. Epub 2017 Oct 12. J Med Chem. 2017. PMID: 28902994
Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome.
Gasparik V, Greney H, Schann S, Feldman J, Fellmann L, Ehrhardt JD, Bousquet P. Gasparik V, et al. Among authors: schann s. J Med Chem. 2015 Jan 22;58(2):878-87. doi: 10.1021/jm501456p. Epub 2014 Dec 31. J Med Chem. 2015. PMID: 25521963
24 results