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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M. Lederhofer J, et al. Among authors: graham bs. Immunity. 2024 Mar 12;57(3):574-586.e7. doi: 10.1016/j.immuni.2024.02.003. Epub 2024 Mar 1. Immunity. 2024. PMID: 38430907 Free article.
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups.
Hutchinson G, Abiona O, Ziwawo C, Werner A, Ellis D, Tsybovsky Y, Leist S, Palandjian C, West A, Fritch E, Wang N, Wrapp D, Boyoglu-Barnum S, Ueda G, Baker D, Kanekiyo M, McLellan J, Baric R, King N, Graham B, Corbett K. Hutchinson G, et al. Res Sq [Preprint]. 2022 Nov 7:rs.3.rs-2199814. doi: 10.21203/rs.3.rs-2199814/v1. Res Sq. 2022. Update in: Nat Commun. 2023 Oct 4;14(1):6195. doi: 10.1038/s41467-023-41661-4 PMID: 36380759 Free PMC article. Updated. Preprint.
Antigen spacing on protein nanoparticles influences antibody responses to vaccination.
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP. Ellis D, et al. Among authors: graham bs. bioRxiv [Preprint]. 2023 May 24:2023.05.23.541980. doi: 10.1101/2023.05.23.541980. bioRxiv. 2023. Update in: Cell Rep. 2023 Dec 26;42(12):113552. doi: 10.1016/j.celrep.2023.113552 PMID: 37292995 Free PMC article. Updated. Preprint.
Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.
Ols S, Lenart K, Arcoverde Cerveira R, Miranda MC, Brunette N, Kochmann J, Corcoran M, Skotheim R, Philomin A, Cagigi A, Fiala B, Wrenn S, Marcandalli J, Hellgren F, Thompson EA, Lin A, Gegenfurtner F, Kumar A, Chen M, Phad GE, Graham BS, Perez L, Borst AJ, Karlsson Hedestam GB, Ruckwardt TJ, King NP, Loré K. Ols S, et al. Among authors: graham bs. Immunity. 2023 Oct 10;56(10):2425-2441.e14. doi: 10.1016/j.immuni.2023.08.011. Epub 2023 Sep 8. Immunity. 2023. PMID: 37689061 Free article.
Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures.
Kanekiyo M, Gillespie RA, Midgett M, O'Malley KJ, Williams C, Moin SM, Wallace M, Treaster L, Cooper K, Syeda H, Kettenburg G, Rannulu H, Schmer T, Ortiz L, Da Silva Castanha P, Corry J, Xia M, Olsen E, Perez D, Yun G, Graham BS, Barratt-Boyes SM, Reed DS. Kanekiyo M, et al. Among authors: graham bs. iScience. 2023 Sep 6;26(10):107830. doi: 10.1016/j.isci.2023.107830. eCollection 2023 Oct 20. iScience. 2023. PMID: 37766976 Free PMC article.
Antigen spacing on protein nanoparticles influences antibody responses to vaccination.
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP. Ellis D, et al. Among authors: graham bs. Cell Rep. 2023 Dec 26;42(12):113552. doi: 10.1016/j.celrep.2023.113552. Epub 2023 Dec 13. Cell Rep. 2023. PMID: 38096058 Free PMC article.
Prefusion stabilization of the Hendra and Langya virus F proteins.
Byrne PO, Blade EG, Fisher BE, Ambrozak DR, Ramamohan AR, Graham BS, Loomis RJ, McLellan JS. Byrne PO, et al. Among authors: graham bs. J Virol. 2024 Feb 20;98(2):e0137223. doi: 10.1128/jvi.01372-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214525 Free PMC article.
Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem.
Ataca S, Sangesland M, de Paiva Fróes Rocha R, Torrents de la Peña A, Ronsard L, Boyoglu-Barnum S, Gillespie RA, Tsybovsky Y, Stephens T, Moin SM, Lederhofer J, Creanga A, Andrews SF, Barnes RM, Rohrer D, Lonberg N, Graham BS, Ward AB, Lingwood D, Kanekiyo M. Ataca S, et al. Among authors: graham bs. Cell Rep. 2024 Dec 24;43(12):114990. doi: 10.1016/j.celrep.2024.114990. Epub 2024 Nov 22. Cell Rep. 2024. PMID: 39580804 Free PMC article.
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies.
Lederhofer J, Borst AJ, Nguyen L, Gillespie RA, Williams CJ, Walker EL, Raab JE, Yap C, Ellis D, Creanga A, Tan HX, Do THT, Ravichandran M, McDermott AB, Sage VL, Andrews SF, Graham BS, Wheatley AK, Reed DS, King NP, Kanekiyo M. Lederhofer J, et al. Among authors: graham bs. bioRxiv [Preprint]. 2024 Dec 3:2024.11.27.625426. doi: 10.1101/2024.11.27.625426. bioRxiv. 2024. PMID: 39677750 Free PMC article. Preprint.
587 results